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气管副神经节瘤的多学科管理:血管造影栓塞和手术切除病例报告及文献综述

Multidisciplinary management of tracheal paraganglioma with angiographic embolization and surgical excision: A case report and review of literature.

作者信息

Jalili Javad, Amiri AhmadReza, Rasi Hashemi Seyed Ziyaeddin, Rezaei Sahar, Mikaeeli Mohammadreza, Karbasi Mahsa, Vaseghi Sarah

机构信息

Department of Interventional Radiology, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Medicine (Baltimore). 2025 Aug 1;104(31):e42712. doi: 10.1097/MD.0000000000042712.

DOI:10.1097/MD.0000000000042712
PMID:40760604
Abstract

RATIONALE

Tracheal paragangliomas (PGs) are exceedingly rare tumors originating from chromaffin cells. They often present with nonspecific symptoms like dyspnea and hemoptysis, which can mimic more common respiratory conditions such as asthma.

PATIENT CONCERNS

We present the case of a 58-year-old female initially diagnosed with asthma who later experienced recurrent hemoptysis and worsening dyspnea.

DIAGNOSES

Rigid bronchoscopy revealed a vegetative mass located 2 cm below the vocal cords, and a biopsy confirmed PG. Cross-sectional imaging identified a lobulated lesion on the posterior tracheal wall.

INTERVENTIONS

To prevent excessive bleeding, angiographic embolization was performed before bronchoscopic surgical resection, involving super-selective catheterization of the tumor's arterial feeder.

OUTCOMES

The embolization successfully reduced vascularity, facilitating safe tumor resection. The patient remains symptom-free at the 1-year follow-up, indicating effective management of the condition.

LESSONS

This case highlights the importance of a multidisciplinary approach in diagnosing and treating tracheal PGs. Preoperative embolization is crucial for managing bleeding risks associated with these highly vascular tumors. Detailed insights into the angiographic procedure are provided, along with a systematic review of similar cases.

摘要

理论依据

气管副神经节瘤(PGs)是起源于嗜铬细胞的极其罕见的肿瘤。它们常表现为呼吸困难和咯血等非特异性症状,可类似于哮喘等更常见的呼吸系统疾病。

患者情况

我们报告一例58岁女性病例,该患者最初被诊断为哮喘,后来反复咯血且呼吸困难加重。

诊断

硬质支气管镜检查发现声门下2 cm处有一赘生物,活检确诊为PG。横断面成像显示气管后壁有一分叶状病变。

干预措施

为防止过度出血,在支气管镜手术切除前进行了血管造影栓塞,包括对肿瘤供血动脉进行超选择性插管。

结果

栓塞成功减少了血管供应,便于安全切除肿瘤。患者在1年随访时无症状,表明病情得到有效控制。

经验教训

该病例强调了多学科方法在气管PGs诊断和治疗中的重要性。术前栓塞对于管理与这些高血管性肿瘤相关的出血风险至关重要。提供了血管造影手术的详细见解,并对类似病例进行了系统回顾。

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本文引用的文献

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Management dilemmas of tracheal paraganglioma: a case report and review of literature.气管副神经节瘤的治疗困境:病例报告及文献复习。
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Pitfalls in the management of subglottic paragangliomas at unusual location: a case report and literature review.位于非典型位置的声门下副神经节瘤的处理陷阱:病例报告及文献复习。
BMC Surg. 2021 Sep 8;21(1):340. doi: 10.1186/s12893-021-01337-6.
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Tracheal Paraganglioma: A Case report and Review of the Pertinent Literature.
气管副神经节瘤:病例报告及相关文献复习。
Intern Med. 2021 Jul 15;60(14):2275-2283. doi: 10.2169/internalmedicine.5705-20. Epub 2021 Feb 15.
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Thyroid paraganglioma accompanied by lymph node metastasis or trachea invasion: A case report.甲状腺副神经节瘤伴淋巴结转移或气管侵犯:病例报告
Oncol Lett. 2020 Dec;20(6):345. doi: 10.3892/ol.2020.12208. Epub 2020 Oct 8.
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Pheochromocytoma and Paraganglioma.嗜铬细胞瘤和副神经节瘤。
N Engl J Med. 2019 Aug 8;381(6):552-565. doi: 10.1056/NEJMra1806651.
6
Non-circumferential membranous resection of the trachea for paraganglioma: A case report.气管节细胞神经瘤的非环形膜性切除术:一例报告
Int J Surg Case Rep. 2018;51:288-291. doi: 10.1016/j.ijscr.2018.09.016. Epub 2018 Sep 17.
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Tracheal paraganglioma presenting as stridor in a pediatric patient, case report and literature review.小儿患者以喘鸣为表现的气管副神经节瘤:病例报告及文献综述
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Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.嗜铬细胞瘤和副神经节瘤:内分泌学会临床实践指南
J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498.
9
Tracheal paraganglioma: differential diagnosis of a contrast-enhanced tracheal mass.气管副神经节瘤:增强CT显示气管肿物的鉴别诊断
AJR Am J Roentgenol. 2014 Jun;202(6):W598. doi: 10.2214/AJR.13.11764.
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Tracheal paraganglioma: an unusual neoplasm of the upper airway.气管副神经节瘤:上呼吸道的一种不常见肿瘤。
Ann Thorac Surg. 2012 May;93(5):1717-9. doi: 10.1016/j.athoracsur.2011.09.053.