Batouti Mervette El, El-Mossalamy El sayedH, Aldesouky Jihad M, Khashaba Mohamed A, Fetouh Howida A
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Chemistry Department, Faculty of Science, Benha University, Banha, Egypt.
BMC Chem. 2025 Aug 4;19(1):231. doi: 10.1186/s13065-025-01592-1.
For mitigating the wide spread antibiotic-resistant bacteria. This study aims: Simple synthesis of new series of coordination metal complexes: Cu(II), Co(II), Sm(III), Gd(III) and Tb(III) from the prepared Schiff base bis-hydrazones ligands I-VIII (derivatives of glyoxal, biacetyl and benzyl-hydroxybenzaldhyde and methoxysalicaldhyde). Structural features derived from elemental analysis (empirical formula), melting point (purity), nuclear magnetic resonance (H, C) spectra and mass spectra. Vibrational IR spectra confirmed strong bonding between metal ions and ligands assumed the coordination sites are oxygen and nitrogen atoms of carbonyl C = O and azomethine CH = N groups. H-NMR spectra (chemical shift 3.5 ppm-10.388 ppm) confirmed all protons in the Schiff bases. Surface analysis SEM micrographs confirmed modified microstructure of 5 ligand (LV) on complexation to Cu(II). Complex CuLV showed particle size range 276-367 nm. Optical activities of the metal complexes confirmed from electronic absorption spectra. Cu(II) complexes showed internal charge transfer bands. Powder X-ray diffraction pattern confirmed that CuLV complex formed in nm scale crystal with particle size range 13.91-35.49 nm. This complex is a potent antimicrobial agent in terms of the wide inhibition zone and low minimum inhibitory concentration (MIC) except for the fungi A.Niger and C.Glabrata (MIC 100 µgL and 400 µgL respectively).The promising inhibition of bacteria growth and low MIC suggested this metal complex as a new antibiotic. For its optimized geometry, molecular docking analysis predicted antibacterial activity and confirmed the observed weak antifungal activity corresponding to high MIC for A.Niger and C. Glabrata fungal species.
为了缓解广泛传播的抗生素抗性细菌。本研究旨在：从制备的席夫碱双腙配体I - VIII（乙二醛、联乙酰、苄基 - 羟基苯甲醛和甲氧基水杨醛的衍生物）简单合成一系列新的配位金属配合物：Cu(II)、Co(II)、Sm(III)、Gd(III)和Tb(III)。通过元素分析（经验式）、熔点（纯度）、核磁共振（H、C）光谱和质谱得出结构特征。振动红外光谱证实金属离子与配体之间有强键合，推测配位位点是羰基C = O的氧原子和氮原子以及甲亚胺CH = N基团。H - NMR光谱（化学位移3.5 ppm - 10.388 ppm）证实了席夫碱中的所有质子。表面分析扫描电子显微镜图像证实了5号配体（LV）与Cu(II)络合后微观结构的改变。络合物CuLV的粒径范围为276 - 367 nm。从电子吸收光谱证实了金属配合物的光学活性。Cu(II)配合物显示出内部电荷转移带。粉末X射线衍射图谱证实CuLV络合物以纳米级晶体形式形成，粒径范围为13.91 - 35.49 nm。除了黑曲霉和光滑念珠菌（最低抑菌浓度分别为100 µg/L和400 µg/L）外，该络合物在宽抑菌圈和低最低抑菌浓度（MIC）方面是一种有效的抗菌剂。对细菌生长的有前景的抑制作用和低MIC表明这种金属络合物是一种新型抗生素。由于其优化的几何结构，分子对接分析预测了抗菌活性，并证实了观察到的对黑曲霉和光滑念珠菌真菌物种对应高MIC的弱抗真菌活性。
