Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Chemistry Department, Faculty of Science, Benha University, Banha, Egypt.
Sci Rep. 2024 Oct 30;14(1):26184. doi: 10.1038/s41598-024-75800-8.
New Schiff base ligand: 4-methoxy salicaldhyde-2-2-phenyl-hydrazono acetaldehíyde prepared by facile method. The molecular structures characterized by elemental analysis and proton magnetic resonance spectra (H-NMR spectra). This spectra at the chemical shifts (3.5-10.39 ppm) confirmed the types and the numbers of protons. The sharp melting point at the range 110-112 °C confirmed purity. New optically active metal (samarium, terbium and gadolinium) complexes of the Schiff base synthesized in a one pot reaction. Vibrational IR spectra confirmed functional groups. Scanning electron microscopy micrographs confirmed that the modified microstructure of the metal complexes differed in morphology than the ligand. Powder X-ray diffraction patterns confirmed good crystalline structure. The optically activity of the solid metal complexes confirmed from electronic absorption spectra. The UV absorbance band at the wavelength range 280-390 nm and the intense phosphorescence bands up to 830 nm enabled application in photo dynamic therapy for apoptosis cancer cells by conversion triplet oxygen in the tissues into reactive singlet oxygen. Low charge transfer energy: 2.59-2.61 eV, high molar extinction coefficients (ε) at the order of magnitude [Formula: see text] M cm and the intense phosphorescence bands reflected good photodynamic activity. The metal complexes are thermally stable.
通过简便的方法制备的 4-甲氧基水杨醛-2-2-苯基腙乙醛。通过元素分析和质子磁共振谱（H-NMR 谱）对分子结构进行了表征。这些谱在化学位移（3.5-10.39 ppm）处证实了质子的类型和数量。在 110-112°C 的范围内的尖锐熔点证实了纯度。在一锅反应中合成了新型手性金属（钐、铽和钆）希夫碱配合物。红外振动光谱证实了官能团。扫描电子显微镜照片证实了金属配合物的改性微观结构在形态上与配体不同。粉末 X 射线衍射图谱证实了良好的结晶结构。从电子吸收光谱证实了固体金属配合物的手性。在 280-390nm 的波长范围内的紫外吸收带和高达 830nm 的强磷光带使它们能够通过将组织中的三重态氧转化为反应性单重态氧，应用于光动力疗法治疗凋亡癌细胞。低电荷转移能量：2.59-2.61eV，摩尔消光系数（ε）在[Formula: see text]M cm 的数量级，强磷光带反映了良好的光动力活性。金属配合物热稳定性好。
