Smith R C, Davis J M
Psychopharmacology (Berl). 1977 Jun 6;53(1):1-12. doi: 10.1007/BF00426687.
The comparative effects of d-amphetamine, l-amphetamine, and methylphenidate were assessed in 16 normal subjects, using a double-blind, crossover placebo-controlled design. Within the dose range tested, the efficacy ratio of d-amphetamine:l-amphetamine was about 2:1, and graphic presentation of dose response scores indicated a relatively small difference in potency between the amphetamine isomers. Methylphenidate was intermediate in efficacy between d-amphetamine and l-amphetamine. The efficacy ratios for d-amphetamine:l-amphetamine on increasing euphoric mood in man were similar to the previously reported ratios of there two isomers in inducing or exacerbating psychosis in humans. These findings do not support the suggestion, made by Snyder and others, that the differential effects of d-amphetamine vs. l-amphetamine on a specific type of behavior in man could be utilized to infer the predominance of noradrenergic vs. dopaminergic mediation of amphetamine's effects on this behavior.
采用双盲、交叉、安慰剂对照设计，在16名正常受试者中评估了右旋苯丙胺、左旋苯丙胺和哌甲酯的比较效应。在所测试的剂量范围内，右旋苯丙胺与左旋苯丙胺的效价比约为2:1，剂量反应评分的图表显示苯丙胺异构体之间的效价差异相对较小。哌甲酯的疗效介于右旋苯丙胺和左旋苯丙胺之间。右旋苯丙胺与左旋苯丙胺在增强人类欣快感方面的效价比与之前报道的这两种异构体在诱发或加重人类精神病方面的效价比相似。这些发现不支持斯奈德等人提出的观点，即右旋苯丙胺与左旋苯丙胺对人类特定类型行为的不同作用可用于推断去甲肾上腺素能与多巴胺能介导苯丙胺对该行为的影响的优势。
