Clifford D B, Podolsky A, Zorumski C F
Epilepsia. 1985 Nov-Dec;26(6):689-92. doi: 10.1111/j.1528-1157.1985.tb05712.x.
The effects of lithium chloride on seizure activity generated by stimulation of hippocampal kindled rats were studied. Acute administration of 0, 0.25, 0.50, 1.5, 3.0, and 5.0 mEq/kg i.p. resulted in serum levels ranging from clinically subtherapeutic to toxic during the subsequent 4 h. Afterdischarge threshold and seizure severity were unchanged by these levels of lithium. Afterdischarge duration was somewhat prolonged, reaching a significant level only for the 3.0-mEq/kg dose. It is concluded that lithium shows a minor proconvulsant effect after acute administration in the kindled hippocampal seizure model.
研究了氯化锂对电刺激海马点燃大鼠所产生的癫痫活动的影响。腹腔注射0、0.25、0.50、1.5、3.0和5.0毫当量/千克的氯化锂后，在随后4小时内血清水平从临床亚治疗范围到中毒范围不等。这些锂水平并未改变后放电阈值和癫痫严重程度。后放电持续时间有所延长，仅在3.0毫当量/千克剂量时达到显著水平。结论是，在点燃海马癫痫模型中，急性给药后锂显示出轻微的促惊厥作用。
