Kofman O, Sherman W R, Katz V, Belmaker R H
Ida and Solomon Stern Psychiatry Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel.
Psychopharmacology (Berl). 1993;110(1-2):229-34. doi: 10.1007/BF02246978.
Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20-24 h prior to the subcutaneous injection of pilocarpine, 20 or 30 mg/kg. In both experiments, myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score. myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of cortical myo-inositol in rats injected with myo-inositol were approximately double those of the CSF and L-chiro-inositol groups.
大鼠锂预处理可增强毛果芸香碱和其他胆碱能激动剂的致痫作用。为了确定锂的这种作用是否可被肌醇逆转，给大鼠进行脑室内（ICV）注射肌醇、人工脑脊液或L-手性肌醇预处理。在皮下注射20或30mg/kg毛果芸香碱前20 - 24小时，腹腔注射3meq/kg氯化锂。在两个实验中，肌醇均显著延长阵挛性发作出现的潜伏期并降低毛果芸香碱癫痫发作评分。肌醇可预防50%接受20mg/kg毛果芸香碱的大鼠出现阵挛性发作。注射肌醇的大鼠皮质肌醇水平约为脑脊液和L-手性肌醇组的两倍。
