Yanagawa T, Hoel D G
Environ Health Perspect. 1985 Nov;63:217-24. doi: 10.1289/ehp.8563217.
Statistical methods for the use of historical control data in testing for a trend in proportions in carcinogenicity rodent bioassays are reviewed. Asymptotic properties of the Hoel-Yanagawa exact conditional tests are developed and compared with the Tarone test. It is indicated that the Hoel-Yanagawa test is more powerful than the Tarone test. These tests depend on the beta-binomial parameters which are estimated from historical data. The goodness of fit of beta-binomial distributions to historical data is illustrated by application to the historical control database in the National Toxicology Program. Finally, sensitivities of the exact conditional test to the historical information is discussed and a conservative use of the test is considered.
回顾了在致癌性啮齿动物生物测定中使用历史对照数据检验比例趋势的统计方法。开发了Hoel-Yanagawa精确条件检验的渐近性质，并与Tarone检验进行了比较。结果表明，Hoel-Yanagawa检验比Tarone检验更具功效。这些检验依赖于从历史数据估计的β-二项式参数。通过应用于国家毒理学计划中的历史对照数据库，说明了β-二项式分布对历史数据的拟合优度。最后，讨论了精确条件检验对历史信息的敏感性，并考虑了该检验的保守使用。
