Dechsupa Sinsuda, Yingsakmongkol Wicharn, Limthongkul Worawat, Singhatanadgige Weerasak, Assawakosri Suvichada, Honsawek Sittisak
Center of Excellence in Osteoarthritis and Musculoskeleton, Department of Biochemistry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopaedics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Clin Transl Sci. 2025 Aug;18(8):e70315. doi: 10.1111/cts.70315.
Degenerative lumbar disease is a significant contributor to acute or chronic musculoskeletal issues in the elderly, often associated with low serum 25-hydroxyvitamin D (25(OH)D) levels. The effect of vitamin D supplementation on muscle mass, strength, and physical performance remains unclear. This study aimed to determine the effect of vitamin D supplementation on these parameters in patients with degenerative lumbar disease and low vitamin D status. A total of 115 patients with serum 25(OH)D levels < 30 ng/mL were administered 40,000 IU of vitamin D (ergocalciferol) weekly for 6 months. Body composition, serum 25(OH)D, parathyroid hormone (PTH) levels, muscle strength, and physical performance were examined before and after 6 months of vitamin D supplementation. Baseline median serum 25(OH)D was 24.9 ng/mL; 79.1% had vitamin D insufficiency, and 20.9% had vitamin D deficiency. After supplementation, median 25(OH)D increased to 43.1 ng/mL (p < 0.001), with a significant reduction in PTH (p < 0.001). Significant improvements were observed in muscle mass (p = 0.04), balance test (p = 0.01), gait speed (p = 0.009), chair stand test (p < 0.001), short physical performance (p < 0.001), Oswestry disability index (p < 0.001), and visual analog scale (VAS) scores (p < 0.001). Post-supplementation 25(OH)D levels correlated negatively with body mass index (ρ = -0.187, p = 0.045), fat mass (ρ = -0.219, p = 0.019), fat percentage (ρ = -0.199, p = 0.033), and VAS score (ρ = -0.313, p < 0.001). Six months of vitamin D supplementation significantly improved vitamin D status, muscle mass, physical performance, and quality of life in patients with degenerative lumbar disease.
退行性腰椎疾病是导致老年人急性或慢性肌肉骨骼问题的一个重要因素，常与血清25-羟基维生素D（25(OH)D）水平低有关。补充维生素D对肌肉质量、力量和身体机能的影响仍不明确。本研究旨在确定补充维生素D对患有退行性腰椎疾病且维生素D水平低的患者这些参数的影响。共有115名血清25(OH)D水平<30 ng/mL的患者，每周服用40,000 IU维生素D（麦角钙化醇），持续6个月。在补充维生素D 6个月前后，对身体成分、血清25(OH)D、甲状旁腺激素（PTH）水平、肌肉力量和身体机能进行了检查。基线时血清25(OH)D中位数为24.9 ng/mL；79.1%的人维生素D不足，20.9%的人维生素D缺乏。补充后，25(OH)D中位数增至43.1 ng/mL（p<0.001），PTH显著降低（p<0.001）。在肌肉质量（p=0.04）、平衡测试（p=0.01）、步速（p=0.009）、椅子起立测试（p<0.001）、简短身体机能测试（p<0.001）、Oswestry功能障碍指数（p<0.001）和视觉模拟评分（VAS）（p<0.001）方面观察到显著改善。补充后25(OH)D水平与体重指数（ρ=-0.187，p=0.045）、脂肪量（ρ=-0.219，p=0.019）、脂肪百分比（ρ=-0.199，p=0.033）和VAS评分（ρ=-0.313，p<0.001）呈负相关。补充6个月维生素D可显著改善退行性腰椎疾病患者的维生素D状态、肌肉质量、身体机能和生活质量。
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