Jiang Yongliang, Xu Chongxi, Ma Junpeng, Luo Tianyou
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Oncol. 2025 Jul 21;15:1555098. doi: 10.3389/fonc.2025.1555098. eCollection 2025.
Giant Cell Tumor of the Tendon Sheath (GCTTS) is a rare neoplasm that can exhibit local aggressiveness but is generally benign. GCTTS is commonly classified into two subtypes: localized and diffuse, and rarely affects the axial skeleton. Diagnosing GCTTS in the spine is challenging, and it is associated with localized pain and neurological symptoms. Surgical resection is now the preferred treatment, though recurrence rates remain high. This report describes an exceptionally rare case of rapidly progressive and extensively invasive diffuse GCTTS affecting the lateral joints, surrounding vasculature, and nerves of the cervical spine. We also review the clinical presentation, imaging characteristics, and therapeutic outcomes of spinal GCTTS to enhance understanding and awareness of this rare pathology.
腱鞘巨细胞瘤（GCTTS）是一种罕见的肿瘤，可表现出局部侵袭性，但通常为良性。GCTTS通常分为两种亚型：局限性和弥漫性，很少累及中轴骨骼。在脊柱中诊断GCTTS具有挑战性，且与局部疼痛和神经症状相关。手术切除目前是首选治疗方法，尽管复发率仍然很高。本报告描述了一例极其罕见的快速进展且广泛侵袭性的弥漫性GCTTS病例，该病例累及颈椎的外侧关节、周围血管和神经。我们还回顾了脊柱GCTTS的临床表现、影像学特征和治疗结果，以增进对这种罕见病理的理解和认识。
