Pardo José V
Cognitive Neuroimaging Unit, Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.
Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA.
J Psychiatr Brain Sci. 2021;6(5). doi: 10.20900/jpbs.20210019. Epub 2021 Oct 27.
To date, no gene following Mendelian inheritance (e.g., monogenic variant) has been discovered for any common psychiatric disorder. This unfortunate circumstance has delayed meaningful inroads into the pathophysiology of psychiatric disease that has otherwise enabled advances into so many other fields of medicine. New methods and approaches can now find these putative genes offering the same potential for foundational impact on psychiatry as has occurred in diverse fields such as metabolism, hematology, and cancer. If unsuccessful, a significant impediment in progress toward mitigating the suffering from mental illness will result.
迄今为止，尚未发现任何常见精神疾病遵循孟德尔遗传规律的基因（例如单基因变异）。这一不幸情况延缓了我们对精神疾病病理生理学的深入理解，而在其他众多医学领域却取得了进展。现在，新的方法和途径能够找到这些假定基因，有望像在代谢、血液学和癌症等不同领域那样，为精神病学带来基础性的突破。如果未能成功，将会严重阻碍减轻精神疾病痛苦的进程。
