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一种采用根治性去顶和上皮剥脱术治疗化脓性汗腺炎的新方法。

A Novel Treatment of Hidradenitis Suppurativa With Radical Unroofing and Deepithelialization.

作者信息

Choi Dylan G, Liao Christopher D, Krajewski Aleksandra

机构信息

From the Division of Plastic and Reconstructive Surgery, Renaissance School of Medicine of Stony Brook University, Stony Brook, NY.

出版信息

Plast Reconstr Surg Glob Open. 2025 Aug 4;13(8):e7040. doi: 10.1097/GOX.0000000000007040. eCollection 2025 Aug.

DOI:10.1097/GOX.0000000000007040
PMID:40761628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12321450/
Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disease beginning with hyperkeratosis of the hair follicles in the dermis and leading to inflammation involving adjacent apocrine glands. HS has significant functional and psychological sequelae, but there is currently no standardized algorithm for treatment. For more severe cases of HS, wide surgical excision remains a standard method of treatment to address the underlying fibrosis and sinus tract formation. However, wide local excision to the subcutaneous fat often entails a multistage recovery and is associated with prolonged wound healing and hospitalization. In hopes of decreasing this burden of care and providing a less invasive method of surgical treatment, the authors propose a single-stage operation involving radical unroofing and deepithelialization with simultaneous split-thickness skin grafting.

摘要

化脓性汗腺炎(HS)是一种慢性炎症性疾病,始于真皮层毛囊的角化过度,并导致相邻顶泌汗腺发生炎症。HS具有显著的功能和心理后遗症,但目前尚无标准化的治疗方案。对于更严重的HS病例,广泛手术切除仍然是解决潜在纤维化和窦道形成的标准治疗方法。然而,广泛切除至皮下脂肪通常需要多阶段恢复,且与伤口愈合延长和住院时间延长相关。为了减轻这种护理负担并提供一种侵入性较小的手术治疗方法,作者提出了一种单阶段手术,包括根治性去顶和去上皮化,同时进行中厚皮片移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/94303a0bd29f/gox-13-e7040-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/0f7b0b7ab164/gox-13-e7040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/943475c79723/gox-13-e7040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/816a6666d3f7/gox-13-e7040-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/94303a0bd29f/gox-13-e7040-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/0f7b0b7ab164/gox-13-e7040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/943475c79723/gox-13-e7040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/816a6666d3f7/gox-13-e7040-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f98d/12321450/94303a0bd29f/gox-13-e7040-g004.jpg

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本文引用的文献

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Surgical Management of Hidradenitis Suppurativa.化脓性汗腺炎的外科治疗
Plast Reconstr Surg Glob Open. 2024 Jun 13;12(6):e5860. doi: 10.1097/GOX.0000000000005860. eCollection 2024 Jun.
2
The Role of Intra-Follicular Shear Forces in Hidradenitis Suppurativa.毛囊内剪切力在化脓性汗腺炎中的作用
Skin Pharmacol Physiol. 2023;36(6):302-303. doi: 10.1159/000536067. Epub 2024 Jan 4.
3
One-Stage Coverage of Leg Region Defects with STSG Combined with VAC Dressing Improves Early Patient Mobilisation and Graft Take: A Comparative Study.
自体断层皮片移植联合负压封闭引流术一期覆盖腿部区域缺损可改善患者早期活动能力及植皮成活率:一项对比研究
J Clin Med. 2022 Jun 9;11(12):3305. doi: 10.3390/jcm11123305.
4
Surgical Treatment in Hidradenitis Suppurativa.化脓性汗腺炎的手术治疗
J Clin Med. 2022 Apr 21;11(9):2311. doi: 10.3390/jcm11092311.
5
Split-thickness skin graft donor-site morbidity: A systematic literature review.分层皮片供皮区发病率:一项系统文献综述。
Burns. 2021 Nov;47(7):1525-1546. doi: 10.1016/j.burns.2021.02.014. Epub 2021 Feb 25.
6
Cost-Effectiveness of the Use of Autologous Cell Harvesting Device Compared to Standard of Care for Treatment of Severe Burns in the United States.美国重度烧伤治疗中使用自体细胞采集设备与标准治疗相比的成本效益。
Adv Ther. 2019 Jul;36(7):1715-1729. doi: 10.1007/s12325-019-00961-2. Epub 2019 May 7.
7
Proceeding report of the third symposium on Hidradenitis Suppurativa advances (SHSA) 2018.第三届化脓性汗腺炎进展研讨会(SHSA)2018 会议报告
Exp Dermatol. 2019 Jul;28(7):769-775. doi: 10.1111/exd.13928. Epub 2019 Apr 29.
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Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model.化脓性汗腺炎:将炎症途径整合到一个连贯的致病模型中的系统评价。
Front Immunol. 2018 Dec 14;9:2965. doi: 10.3389/fimmu.2018.02965. eCollection 2018.
9
Wide excision and healing by secondary intent for the surgical treatment of hidradenitis suppurativa: A single-center experience.广泛切除并二期愈合用于化脓性汗腺炎的手术治疗:单中心经验
J Plast Reconstr Aesthet Surg. 2016 Apr;69(4):554-66. doi: 10.1016/j.bjps.2015.12.004. Epub 2016 Jan 5.
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Dermatol Surg. 2013 Dec;39(12):1835-42. doi: 10.1111/dsu.12329. Epub 2013 Oct 1.