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自体断层皮片移植联合负压封闭引流术一期覆盖腿部区域缺损可改善患者早期活动能力及植皮成活率:一项对比研究

One-Stage Coverage of Leg Region Defects with STSG Combined with VAC Dressing Improves Early Patient Mobilisation and Graft Take: A Comparative Study.

作者信息

Sapino Gianluca, Lanz Loise, Roesti Aurore, Guillier David, Deglise Sebastien, De Santis Giorgio, Raffoul Wassim, di Summa Pietro

机构信息

Department of Plastic and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland.

Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland.

出版信息

J Clin Med. 2022 Jun 9;11(12):3305. doi: 10.3390/jcm11123305.

Abstract

Lower limb skin defects are very common and can result from a wide range of aetiologies. Split thickness skin graft (STSG) is a widely used method to address these problems. The role of postoperative dressing is primary as it permits one to apply a uniform pressure over the grafted area and promote adherence. Focusing on lower limb reconstruction, our clinical study compares the application of V.A.C. (Vacuum Assisted Closure) Therapy vs. conventional dressing in the immediate postoperative period following skin grafting. We included in the study all patients who received skin grafts on the leg region between January 2015 and December 2018, despite the aetiology of the defect. Only reconstructions with complete preoperative and postoperative follow-up data were included in the study. Patients were divided into two groups depending on if they received a traditional compressive dressing or a VAC dressing in the immediate postoperative period. We could retain 92 patients, 23 in the No VAC group and 69 in the VAC group. The patients included in the VAC group showed a statistically significant higher rate of graft take together with a lower immobilisation time (p < 0.05). Moreover, a lower rate of postoperative infection was recorded in the VAC group. This study represents the largest in the literature to report in detail surgical outcomes comparing the use of VAC therapy vs. conventional dressing after STSG in the postoperative management of lower limb reconstruction using skin grafts. VAC therapy was used to secure the grafts in the leg region, increasing the early graft take rate while at the same time improving patient mobilisation.

摘要

下肢皮肤缺损非常常见,可由多种病因引起。断层皮片移植(STSG)是解决这些问题的一种广泛应用的方法。术后敷料的作用至关重要,因为它能使人们在移植区域施加均匀压力并促进粘连。针对下肢重建,我们的临床研究比较了负压封闭引流(V.A.C.)疗法与传统敷料在皮肤移植术后即刻的应用情况。我们纳入了2015年1月至2018年12月期间在腿部接受皮肤移植的所有患者,无论缺损的病因如何。该研究仅纳入了术前和术后有完整随访数据的重建病例。根据患者在术后即刻接受的是传统加压敷料还是VAC敷料,将其分为两组。我们共保留了92例患者,其中非VAC组23例,VAC组69例。VAC组患者的皮片成活率在统计学上显著更高,且固定时间更短(p < 0.05)。此外,VAC组术后感染率更低。本研究是文献中最大规模的一项,详细报告了在下肢皮肤移植重建术后管理中比较VAC疗法与传统敷料使用后的手术结果。VAC疗法用于固定腿部区域的移植皮片,提高了早期皮片成活率,同时改善了患者的活动能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dec/9224921/fcb64c02a5ff/jcm-11-03305-g001.jpg

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