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急性肺栓塞溶栓后急性骨筋膜室综合征——病例报告

Acute Compartment Syndrome Post-Thrombolysis for Acute Pulmonary Embolism-A Case Report.

作者信息

Ziblim Andrew Mpagwuni, Ntumi Mawunyo, Baah-Adade Nana Kwame, Agamah Samuel Ofosu, Kunutsor Dziwornu, Acheampong Elizabeth, Salifu Abdul-Wakil Wunpini, Marfoh Augustine Frimpong, Salifu Nyagse, Ofosu-Appiah Ernest

机构信息

Department of Anaesthesia and Intensive Care University of Ghana Medical Centre Legon Ghana.

Orthopaedics Unit, Department of Surgery University of Ghana Medical Centre Legon Ghana.

出版信息

Clin Case Rep. 2025 Aug 3;13(8):e70764. doi: 10.1002/ccr3.70764. eCollection 2025 Aug.

DOI:10.1002/ccr3.70764
PMID:40761678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318672/
Abstract

The use of thrombolysis for acute pulmonary embolism is well established. Thrombolysis poses the risk of mostly minor bleeding; however, intracranial bleeding is the most feared complication. Less recognized is the possibility of limb-threatening complications, such as acute compartment syndrome, which need a high index of suspicion, prompt evaluation, and intervention.

摘要

溶栓疗法用于急性肺栓塞已得到充分确立。溶栓存在主要为轻微出血的风险;然而,颅内出血是最令人担忧的并发症。肢体威胁性并发症,如急性骨筋膜室综合征的可能性则较少被认识到,这需要高度的怀疑指数、及时评估和干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5275/12318672/83e57c3057c4/CCR3-13-e70764-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5275/12318672/83e57c3057c4/CCR3-13-e70764-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5275/12318672/83e57c3057c4/CCR3-13-e70764-g001.jpg

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本文引用的文献

1
Acute Pulmonary Embolism: A Review.急性肺栓塞:综述。
JAMA. 2022 Oct 4;328(13):1336-1345. doi: 10.1001/jama.2022.16815.
2
Thrombolytic therapy for pulmonary embolism.肺栓塞的溶栓治疗
Cochrane Database Syst Rev. 2018 Dec 18;12(12):CD004437. doi: 10.1002/14651858.CD004437.pub5.
3
Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.肺栓塞溶栓治疗与全因死亡率、大出血和颅内出血风险的关系:一项荟萃分析。
JAMA. 2014 Jun 18;311(23):2414-21. doi: 10.1001/jama.2014.5990.
4
Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis.急性肺栓塞的全身溶栓治疗:一项系统评价和荟萃分析。
Eur Heart J. 2015 Mar 7;36(10):605-14. doi: 10.1093/eurheartj/ehu218. Epub 2014 Jun 10.
5
Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial.替奈普酶或安慰剂治疗亚大块肺栓塞:3 个月时的心肺结局:多中心、双盲、安慰剂对照随机试验。
J Thromb Haemost. 2014 Apr;12(4):459-68. doi: 10.1111/jth.12521.
6
Compartment syndrome following thrombolysis: clinical features and associated conditions.溶栓后骨筋膜室综合征:临床特征及相关情况
J Thromb Thrombolysis. 2014;38(2):201-7. doi: 10.1007/s11239-013-1025-6.
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Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism.肺栓塞,第一部分:流行病学、危险因素与风险分层、病理生理学、临床表现、诊断及非血栓性肺栓塞
Exp Clin Cardiol. 2013 Spring;18(2):129-38.
8
CASE REPORT Acute Compartment Syndrome of the Forearm Following Blood Gas Analysis Postthrombolysis for Pulmonary Embolism.病例报告:肺栓塞溶栓治疗后血气分析导致的前臂急性骨筋膜室综合征
Eplasty. 2013;13:e15. Epub 2013 Mar 7.
9
Forearm Compartment Syndrome following Thrombolytic Therapy for Massive Pulmonary Embolism: A Case Report and Review of Literature.溶栓治疗大面积肺栓塞后发生的前臂骨筋膜室综合征:一例报告并文献复习
Case Rep Orthop. 2011;2011:678525. doi: 10.1155/2011/678525. Epub 2012 Jan 23.
10
Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients with pulmonary embolism.替奈普酶推注治疗肺栓塞合并右心功能障碍血流动力学稳定患者。
Thromb Res. 2010 Mar;125(3):e82-6. doi: 10.1016/j.thromres.2009.09.017. Epub 2009 Oct 14.