A wonder drug? new discoveries potentiate new therapeutic potentials of metformin.
作者信息
Matz Alyssa J, Zhou Beiyan
机构信息
Department of Immunology, School of Medicine, University of Connecticut, Farmington, Connecticut, USA.
Institute for Systems Genomics, University of Connecticut, Farmington, Connecticut, USA.
出版信息
Obes Med. 2023 Oct;43. doi: 10.1016/j.obmed.2023.100514. Epub 2023 Oct 6.
Abstract
摘要
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本文引用的文献
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Metformin: update on mechanisms of action and repurposing potential.二甲双胍：作用机制及再利用潜力的最新研究进展。
Nat Rev Endocrinol. 2023 Aug;19(8):460-476. doi: 10.1038/s41574-023-00833-4. Epub 2023 May 2.
2
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition.二甲双胍通过抑制 CXCL1 增加头颈部鳞状细胞癌自然杀伤细胞的功能。
J Immunother Cancer. 2022 Nov;10(11). doi: 10.1136/jitc-2022-005632.
3
Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19.二甲双胍、伊维菌素和氟伏沙明治疗 COVID-19 的随机试验。
N Engl J Med. 2022 Aug 18;387(7):599-610. doi: 10.1056/NEJMoa2201662.
4
Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice.二甲双胍通过调节雌性小鼠的免疫图谱预防与年龄相关的卵巢纤维化。
Sci Adv. 2022 Sep 2;8(35):eabq1475. doi: 10.1126/sciadv.abq1475.
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Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus.二甲双胍增强2型糖尿病老年患者的B细胞功能和抗体反应。
Front Aging. 2021 Jul 23;2:715981. doi: 10.3389/fragi.2021.715981. eCollection 2021.
6
The potential role for metformin in the prevention and treatment of tuberculosis.二甲双胍在结核病预防和治疗中的潜在作用。
J Thorac Dis. 2022 Jun;14(6):1758-1765. doi: 10.21037/jtd-22-39.
7
Metformin treatment rescues CD8 T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD.二甲双胍治疗可挽救非酒精性脂肪性肝病小鼠对免疫检查点抑制剂治疗的 CD8 T 细胞反应。
J Hepatol. 2022 Sep;77(3):748-760. doi: 10.1016/j.jhep.2022.03.010. Epub 2022 Apr 1.
8
Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial.二甲双胍早期治疗对2019冠状病毒病患者急诊和住院风险的影响：TOGETHER随机平台临床试验
Lancet Reg Health Am. 2022 Feb;6:100142. doi: 10.1016/j.lana.2021.100142. Epub 2021 Dec 14.
9
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1.二甲双胍通过抑制 SARS-CoV-2 刺突蛋白亚单位 1 抑制单核细胞免疫代谢激活。
Front Immunol. 2021 Nov 11;12:733921. doi: 10.3389/fimmu.2021.733921. eCollection 2021.
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Nat Commun. 2021 Jan 19;12(1):440. doi: 10.1038/s41467-020-20723-x.
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