Großmann Linus, Cyrus Johanna, Senekowitsch Stefan, Wildgrube Toni, Tzakri Theodora, Kromrey Marie-Luise, Weitschies Werner, Grimm Michael
University of Greifswald, Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
University Hospital Carl Gustav Carus, Institute for Diagnostic and Interventional Radiology, Fetscherstrasse 74, 01307 Dresden, Germany.
Int J Pharm X. 2025 Jul 23;10:100365. doi: 10.1016/j.ijpx.2025.100365. eCollection 2025 Dec.
The (stomach road) is a phenomenon describing the rapid evacuation of water drunken after a solid meal from the stomach. So far, its existence has been demonstrated for water volumes of 150 mL or more. The aim of this three-arm, randomised, cross-over, 12-subject study was to investigate whether the is also present for smaller water volumes. For this purpose, gastric emptying of 50, 100 or 150 mL of water that was administered after a light meal was determined using MR imaging. With each dose of water, a fast-dissolving compression coated tablet containing caffeine and iron oxide as well as a hard capsule containing stable isotope labelled caffeine and medium-chain triglycerides were administered. This made it possible to determine the initial localization of the respective forms in the stomach on MR images as a function of the amount of water drunk, and also to determine the emptying rates of the two caffeine variants using saliva samples that were obtained in the study and quantified using LC-MS/MS. Gastric emptying of the ingested water was rapid and usually completed after approximately 20 min, regardless of the applied volume. In contrast to the consumed water, gastric emptying of natural caffeine and stable isotope labelled caffeine was delayed. The capsule usually floated on liquid and chyme, whereas the compression coated tablet was often embedded in chyme.
（胃路）是一种描述在进食固体食物后胃中快速排空所饮用的水的现象。到目前为止，已证明对于150毫升或更多的水量存在这种现象。这项三臂、随机、交叉、12名受试者的研究目的是调查对于较小水量是否也存在（胃路）现象。为此，使用磁共振成像确定在清淡餐后给予的50、100或150毫升水的胃排空情况。每次给予水时，还给予一片含有咖啡因和氧化铁的速溶压制包衣片以及一个含有稳定同位素标记咖啡因和中链甘油三酯的硬胶囊。这使得能够根据所饮用的水量在磁共振图像上确定各自剂型在胃中的初始定位，并且还能够使用在研究中获得并通过液相色谱 - 串联质谱法定量的唾液样本确定两种咖啡因变体的排空率。无论所应用的水量如何，所摄入水的胃排空都很快，通常在约20分钟后完成。与所消耗的水相反，天然咖啡因和稳定同位素标记咖啡因的胃排空延迟。胶囊通常漂浮在液体和食糜上，而压制包衣片常常嵌入食糜中。
