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研究由间苯二甲酸基低分子量凝胶剂形成的超分子锌(II)金属凝胶的强效抗菌性能。

Investigating the potent antimicrobial properties of a supramolecular Zn(ii)-metallogel formed from an isophthalic acid-based low molecular weight gelator.

作者信息

Dhibar Subhendu, Some Sangita, Pal Suchetana, Laha Rajlakshmi, Kaith Priya, Trivedi Aditi, Bhattacharjee Subham, Nthunya Lebea N, Ajiboye Timothy O, Panja Sumit Kumar, Das Asit Kumar, Bera Ashok, Dam Somasri, Saha Bidyut

机构信息

Colloid Chemistry Laboratory, Department of Chemistry, The University of Burdwan Golapbag Burdwan 713104 West Bengal India

Department of Microbiology, The University of Burdwan Burdwan 713104 West Bengal India

出版信息

RSC Adv. 2025 Aug 4;15(34):27544-27550. doi: 10.1039/d5ra03663a. eCollection 2025 Aug 1.

Abstract

A zinc(ii)-based metallogel was synthesized using isophthalic acid as a gelator in ,-dimethylformamide at room temperature. The gel formation was confirmed by FT-IR spectroscopy, revealing coordination interactions responsible for network assembly. Rheological studies demonstrated the mechanical robustness and stability of the Zn(ii)-metallogel under various conditions. Field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray (EDX) mapping analyses revealed a well-defined microstructure and uniform elemental distribution, providing insight into its morphology and composition. Antimicrobial evaluations showed notable inhibitory effects against both Gram-positive and Gram-negative bacterial strains, underlining the metallogel's broad-spectrum efficacy. These results indicate that the Zn(ii)-isophthalic acid metallogel holds strong promise for applications in antimicrobial materials. Its structural integrity and bioactivity suggest potential utility in biomedical and industrial domains, promoting the development of advanced multifunctional materials.

摘要

在室温下,以间苯二甲酸为凝胶剂,在N,N-二甲基甲酰胺中合成了一种基于锌(II)的金属凝胶。通过傅里叶变换红外光谱(FT-IR)证实了凝胶的形成,揭示了负责网络组装的配位相互作用。流变学研究表明,Zn(II)-金属凝胶在各种条件下具有机械强度和稳定性。场发射扫描电子显微镜(FESEM)和能量色散X射线(EDX)映射分析揭示了明确的微观结构和均匀的元素分布,从而深入了解其形态和组成。抗菌评估显示,该金属凝胶对革兰氏阳性和革兰氏阴性细菌菌株均具有显著的抑制作用,突显了其广谱功效。这些结果表明,Zn(II)-间苯二甲酸金属凝胶在抗菌材料应用方面具有很大的前景。其结构完整性和生物活性表明在生物医学和工业领域具有潜在用途,推动了先进多功能材料的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d02/12319535/05c6c7a506f0/d5ra03663a-f1.jpg

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