Othman Ahmed, Kutkat Omnia, Mabrouk Samar S, Amen Yhiya
Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt
Centre of Scientific Excellence for Influenza Viruses, Water Pollution Research Department, Environment Research and Climate Change Institute, National Research Centre Giza 12622 Egypt
RSC Adv. 2025 Aug 4;15(34):27623-27629. doi: 10.1039/d5ra03089g. eCollection 2025 Aug 1.
Halophytes are well-known as a rich source of health-promoting phytochemicals. This study aimed to elucidate the chemical constituents and antiviral potential of the halophyte Moq., growing in the desert areas of Egypt. Six triterpenoid oleanane saponins (1-6) were purified using several chromatographic procedures and identified HRMS and NMR spectroscopic analyses, with solysaponin B-D being reported for the first time. Additionally, three known triterpene saponins (4-6) were identified as spinacoside C (4), betavulgaroside IV (5), and (3β)-3-(β-d-glucuronopyranosyloxy)olean-12-en-23,28-dioic acid (6). The isolated triterpene saponins were able to inhibit the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). Our study provides valuable insights into the promising antiviral activity of saponins 1, 2 and 4 with IC values ranged between 2.339 and 6.837 μg mL.
盐生植物是众所周知的富含促进健康的植物化学物质的来源。本研究旨在阐明生长在埃及沙漠地区的盐生植物Moq.的化学成分和抗病毒潜力。通过多种色谱方法纯化了六种三萜齐墩果烷皂苷（1-6），并通过高分辨质谱（HRMS）和核磁共振（NMR）光谱分析进行鉴定，其中solysaponin B-D为首次报道。此外，三种已知的三萜皂苷（4-6）被鉴定为菠菜皂苷C（4）、甜菜皂苷IV（5）和（3β）-3-（β-D-葡萄糖醛酸吡喃糖氧基）齐墩果-12-烯-23,28-二酸（6）。分离得到的三萜皂苷能够抑制严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。我们的研究为皂苷1、2和4具有前景的抗病毒活性提供了有价值的见解，其半数抑制浓度（IC）值在2.339至6.837μg/mL之间。
