Nakayama Natsuki, Imai Kuniharu, Niwa Shiori, Moriwaki Yoshimi, Oshima Chika, Furukawa Nozomi, Hirai Makoto
Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Nursing Sciences, Fukui Prefectural University, Fukui, Japan.
Pharmacol Res Perspect. 2025 Aug;13(4):e70159. doi: 10.1002/prp2.70159.
Dyslipidemia, characterized by abnormal serum cholesterol or triglyceride (TG) concentrations, is prevalent among middle-aged and older adults and contributes to atherosclerosis and increased cardiovascular risk. Although oral statins effectively decrease low-density lipoprotein cholesterol, patients with high-TG concentrations remain at significant risk for atherosclerotic cardiovascular disease. Weibull analysis, a statistical method widely applied in reliability engineering and medicine, is suitable for assessing arterial stiffness, which reflects vascular aging or deterioration. This study explored the relationship between TG concentrations and arterial stiffness via Weibull analysis in patients treated with statins (STG) and patients without statin treatment (No-STG). The mode of the Weibull distribution was greater for STG (97.8 mg/dL) than for No-STG (80.7 mg/dL). Notably, compared with No-STG patients, STG patients presented lower hazard functions for TG concentrations up to 170 mg/dL. However, above 170 mg/dL, the hazard function for STG was equal to or slightly greater than that for No-STG. These findings suggest that without statin therapy, atherosclerosis may develop at lower TG concentrations, whereas statins effectively delay its onset. However, the data also highlight the limitations of statins in significantly reducing TG concentrations. This information underscores the importance of patient education in preventing the progression of atherosclerosis. Encouraging lifestyle changes, including improved exercise and dietary habits, can complement statin therapy to optimize cardiovascular health. These findings provide a basis for promoting patient awareness and fostering the proactive management of cardiovascular risk factors.
血脂异常以血清胆固醇或甘油三酯（TG）浓度异常为特征，在中老年人中普遍存在，并会导致动脉粥样硬化和心血管风险增加。尽管口服他汀类药物能有效降低低密度脂蛋白胆固醇，但TG浓度高的患者仍有患动脉粥样硬化性心血管疾病的重大风险。威布尔分析是一种广泛应用于可靠性工程和医学的统计方法，适用于评估反映血管老化或恶化的动脉僵硬度。本研究通过威布尔分析探讨了他汀类药物治疗患者（STG）和未接受他汀类药物治疗患者（No-STG）中TG浓度与动脉僵硬度之间的关系。STG的威布尔分布众数（97.8mg/dL）高于No-STG（80.7mg/dL）。值得注意的是，与No-STG患者相比，STG患者在TG浓度高达170mg/dL时呈现出较低的风险函数。然而，在170mg/dL以上，STG的风险函数等于或略高于No-STG。这些发现表明，在没有他汀类药物治疗的情况下，较低的TG浓度可能会引发动脉粥样硬化，而他汀类药物能有效延迟其发病。然而，数据也凸显了他汀类药物在显著降低TG浓度方面的局限性。这些信息强调了患者教育在预防动脉粥样硬化进展中的重要性。鼓励改变生活方式，包括加强锻炼和改善饮食习惯，可以补充他汀类药物治疗，以优化心血管健康。这些发现为提高患者意识和积极管理心血管危险因素提供了依据。
