Baron Richard, Steenerson Kristen K
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, USA.
Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, USA.
Curr Neurol Neurosci Rep. 2025 Aug 5;25(1):56. doi: 10.1007/s11910-025-01442-6.
Dizziness is a frequent neurologic symptom in patients with headache, which overlaps with many etiologies beyond vestibular migraine. This review aims to help neurologists distinguish when dizziness is due to vestibular migraine (VM) versus other vestibular syndromes.
VM is now recognized as the most common cause of spontaneous episodic vertigo, with expanding diagnostic criteria, new pathophysiological insights involving CGRP, and emerging treatment strategies including anti-CGRP therapies. It overlaps with benign paroxysmal positional vertigo (BPPV), Meniere's disease, persistent postural-perceptual dizziness (PPPD), and cerebrovascular events. Novel tools such as the Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) and frameworks like Timing, Triggers And Targeted Examination (TiTrATE) enhance diagnostic accuracy and patient outcomes. Differentiating VM from other causes of dizziness relies on a detailed clinical history, neurological examination, and increasingly, awareness of VM's protean features and comorbidities. Recognition is essential as treatments can differ significantly across etiologies. Future research should target biomarkers, subtypes and comparative treatment trials for VM and its mimics.
头晕是头痛患者常见的神经系统症状,其病因众多,超出前庭性偏头痛范畴。本综述旨在帮助神经科医生区分头晕何时由前庭性偏头痛(VM)引起,何时由其他前庭综合征引起。
VM现被认为是自发性发作性眩晕最常见的病因,其诊断标准不断扩展,对涉及降钙素基因相关肽(CGRP)的新病理生理学有了深入了解,且出现了包括抗CGRP疗法在内的新治疗策略。它与良性阵发性位置性眩晕(BPPV)、梅尼埃病、持续性姿势 - 知觉性头晕(PPPD)以及脑血管事件存在重叠。诸如前庭性偏头痛患者评估工具和功能障碍量表(VM - PATHI)等新型工具以及像时间、触发因素和针对性检查(TiTrATE)这样的框架提高了诊断准确性和患者治疗效果。将VM与其他头晕病因区分开来依赖于详细的临床病史、神经系统检查,并且越来越依赖于对VM多变特征和合并症的认识。认识到这一点至关重要,因为不同病因的治疗方法可能差异显著。未来研究应针对VM及其模仿疾病的生物标志物、亚型和对比治疗试验。