Gupta Rishi, Pawliuk Colleen, Somuah-Asamoah Denise, Boerner Katelynn E, Engle Jennifer, Hutchison Sarah, Salh Gurpreet K
Sunny Hill Health Center, BC Children's Hospital, Vancouver, British Columbia, Canada.
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
PLoS One. 2025 Aug 5;20(8):e0328845. doi: 10.1371/journal.pone.0328845. eCollection 2025.
The aim of this scoping review is to compare the neurocognitive profiles of children and youth diagnosed with Fetal Alcohol Spectrum Disorder (FASD) to those of children and youth diagnosed with complex trauma.
The neurocognitive challenges resulting from prenatal alcohol exposure (PAE) have been defined by the FASD diagnosis. Complex trauma exposure, in the form of adverse childhood experiences (ACEs), is associated with similar neurocognitive deficits. Recent evidence suggests ACE exposures to be higher in individuals with FASD as compared to non-FASD controls which warrants a closer look at the overlap between the neurocognitive deficits associated with FASD and complex trauma. A more robust understanding comparing the neurocognitive profiles of FASD and complex trauma can guide assessment, diagnosis, and interventions to support the long-term management of youth with cognitive impairments.
The review will assess various studies that evaluate the neurocognitive profiles of FASD and complex trauma amongst the pediatric population (aged 0-18). Complex trauma will be defined as multiple interpersonal traumatic events that happen in childhood. The context of this review is pediatric patients diagnosed with FASD or exposed to complex trauma.
We will search MEDLINE (Ovid), Embase (Ovid), PsycINFO (EBSCO), Scopus and Google Scholar. Additionally, will conduct backwards and forwards citation searching of all included sources. Title and abstract screening and full-text review will be performed by at least two independent reviewers. Data extraction will be performed using a tool developed for this review. The results will be presented in a narrative and tabular format.
本综述的目的是比较被诊断为胎儿酒精谱系障碍(FASD)的儿童和青少年与被诊断为复杂创伤的儿童和青少年的神经认知概况。
胎儿酒精谱系障碍(FASD)诊断已明确了产前酒精暴露(PAE)所导致的神经认知挑战。以童年不良经历(ACEs)形式出现的复杂创伤暴露与类似的神经认知缺陷相关。最近的证据表明,与非FASD对照组相比,FASD个体中ACE暴露更高,这值得更仔细地研究与FASD和复杂创伤相关的神经认知缺陷之间的重叠。更深入地了解FASD和复杂创伤的神经认知概况比较,可为支持认知障碍青少年长期管理的评估、诊断和干预提供指导。
本综述将评估各种研究,这些研究评估儿科人群(0至18岁)中FASD和复杂创伤的神经认知概况。复杂创伤将被定义为童年时期发生的多起人际创伤事件。本综述的背景是被诊断为FASD或暴露于复杂创伤的儿科患者。
我们将检索MEDLINE(Ovid)、Embase(Ovid)、PsycINFO(EBSCO)、Scopus和谷歌学术。此外,将对所有纳入文献进行前后向引文检索。标题和摘要筛选以及全文审查将由至少两名独立评审员进行。数据提取将使用为此综述开发的工具进行。结果将以叙述和表格形式呈现。