哌甲酯预处理对苯丙胺行为及生化反应的影响。
Effect of methylphenidate pretreatment on the behavioral and biochemical responses to amphetamine.
作者信息
Kolta M G, Shreve P, Uretsky N J
出版信息
Eur J Pharmacol. 1985 Nov 5;117(2):279-82. doi: 10.1016/0014-2999(85)90615-6.
After rats were chronically pretreated with methylphenidate (MP), the stereotyped behavioral response to amphetamine (AMPH) was significantly enhanced. In addition, after this pretreatment, the AMPH-induced release of endogenous dopamine from slices of striatum and nucleus accumbens was also enhanced. These effects of MP pretreatment are similar to those reported for AMPH pretreatment and suggest that the sensitization to AMPH that develops after pretreatment with either drug is due to a common mechanism.
大鼠经哌醋甲酯（MP）长期预处理后，对苯丙胺（AMPH）的刻板行为反应显著增强。此外，经过这种预处理后，AMPH诱导的纹状体和伏隔核切片中内源性多巴胺的释放也增强。MP预处理的这些作用与AMPH预处理所报道的作用相似，表明用这两种药物预处理后产生的对AMPH的敏化是由于共同的机制。
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