Chinchay Lyn, Song Kaiyang, Stark Jeffrey, Ward Nicole L, McInnes Iain B
L. Chinchay, MD, MS, Department of Rheumatology, Carita Feliz Clinic, Piura, Peru.
K. Song, BMBCh, Academic Foundation Doctor, Guy's and St Thomas' NHS Foundation Trust, London, UK.
J Rheumatol. 2025 Aug 5. doi: 10.3899/jrheum.2025-0264.
Psoriatic disease (PsD), which includes cutaneous psoriasis (PsO) and psoriatic arthritis (PsA), affects 2% of the global population, and results in the development of comorbidities that adversely affect quality of life (QOL) and physical function. Recent advances in the field have allowed for earlier diagnosis of PsD and improved clinical strategies for care, including the use of innovative pathway-specific immune-targeted therapies. Despite these advances, there is no cure for PsD. Ongoing challenges in disease management include the need for adequate treatment response, precision-based care for individual patients, and a better understanding of the interrelationship between the pathogenesis of cutaneous PsO and PsO comorbidities, including PsA. Future progress may arise from integrating clinical disciplines, harnessing artificial intelligence, using molecular dissection to map out the disease pathogenesis of PsA to identify more effective treatment strategies, and exploring the interplay between PsD and comorbidities including cardiovascular disease, obesity, and depression. These developments could lead to personalized treatment approaches and increase the efficacy of therapeutics for PsD, ultimately improving patient outcomes and QOL. This article highlights the presentation of this topic at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting.
银屑病（PsD）包括皮肤银屑病（PsO）和银屑病关节炎（PsA），影响全球2%的人口，并导致出现对生活质量（QOL）和身体功能产生不利影响的合并症。该领域的最新进展使得能够更早地诊断银屑病，并改进了临床护理策略，包括使用创新的针对特定通路的免疫靶向疗法。尽管有这些进展，但银屑病仍无法治愈。疾病管理中持续存在的挑战包括需要有足够的治疗反应、针对个体患者的精准护理，以及更好地理解皮肤银屑病和银屑病合并症（包括银屑病关节炎）发病机制之间的相互关系。未来的进展可能源于整合临床学科、利用人工智能、使用分子剖析来绘制银屑病关节炎的疾病发病机制以确定更有效的治疗策略，以及探索银屑病与包括心血管疾病、肥胖症和抑郁症在内的合并症之间的相互作用。这些进展可能会带来个性化的治疗方法，并提高银屑病治疗的疗效，最终改善患者的治疗效果和生活质量。本文重点介绍了该主题在银屑病和银屑病关节炎研究与评估小组（GRAPPA）2024年年会上的展示情况。
