Komendantova M V, Zorian E V, Rozhkova V N
Farmakol Toksikol. 1985 Sep-Oct;48(5):28-32.
A study was made of the analgesic action of combined morphine and nonsteroidal anti-inflammatory agents (NAIA)--voltaren, ibuprophen and metindol. It was established that injection of morphine prior to NAIA gives rise to a reduction in the analgesic effect, whereas the combined use of the drugs or administration of NAIA following morphine entails the retention of the effect. Pretreatment with prostaglandin E produces opposite changes in the effect of the analgesics--potentiation of analgesia upon morphine injection and its reduction after NAIA. The data obtained present indirect evidence for the importance of prostaglandins in the antagonism of morphine and NAIA.
对吗啡与非甾体抗炎药（萘普生、布洛芬和甲灭酸）联合使用的镇痛作用进行了研究。结果表明，在使用非甾体抗炎药之前注射吗啡会导致镇痛效果降低，而联合使用这些药物或在吗啡之后使用非甾体抗炎药则能保持镇痛效果。用前列腺素E预处理会使镇痛药的效果产生相反的变化——注射吗啡后镇痛作用增强，使用非甾体抗炎药后镇痛作用减弱。所获得的数据间接证明了前列腺素在吗啡与非甾体抗炎药拮抗作用中的重要性。
