Golovanova I V, Skosyreva A M, Sharova S A, Gus'kova T A
Farmakol Toksikol. 1985 Jan-Feb;48(1):66-9.
The authors studied the tolerance of three nonsteroidal anti-inflammatory drugs, voltaren, indomethacin and ibuprofen by rats at different times of pregnancy and compared voltaren tolerance by pregnant and nonpregnant females. It was shown that as compared to nonpregnant animals, pregnant animals tolerated voltaren more poorly. The tolerance of both voltaren and indomethacin was particularly poor in the last trimester of pregnancy. The enhancement of the drug toxicity during pregnancy because of the changes in body function is discussed.
作者研究了三种非甾体抗炎药（扶他林、消炎痛和布洛芬）在大鼠孕期不同阶段的耐受性，并比较了怀孕和未怀孕雌性大鼠对扶他林的耐受性。结果表明，与未怀孕动物相比，怀孕动物对扶他林的耐受性更差。在怀孕的最后三个月，扶他林和消炎痛的耐受性都特别差。文中讨论了由于身体功能变化导致孕期药物毒性增强的情况。
