Markova I V, Bel'gova I N, Voronkova L A
Farmakol Toksikol. 1985 Sep-Oct;48(5):72-5.
It has been shown on isolated strips of the large intestine of adult and 2-week-old rats that the potassium depolarized smooth muscle of the adult rat intestine reacts by contractions to less concentrations of Ca2+ as compared to 2-week-old rats. Euphylline blocked the reaction of the adult rat large intestine to Ca2+ more powerfully than isoptin. The effects of the spasmolytics on 2-week-old rats were less demonstrable in view of the unremarkable reaction to Ca2+ itself. Both agents reduced the reaction of the adult rat large intestine strips to carbacholine more intensely as compared with 2-week-old rats.
在成年大鼠和2周龄大鼠的离体大肠条上已表明，与2周龄大鼠相比，成年大鼠肠道经钾去极化的平滑肌对较低浓度的Ca2+产生收缩反应。优菲林比异搏定更有效地阻断成年大鼠大肠对Ca2+的反应。鉴于2周龄大鼠本身对Ca2+的反应不明显，解痉药对其作用不太明显。与2周龄大鼠相比，两种药物均更强烈地降低成年大鼠大肠条对卡巴胆碱的反应。
