Markova I V, Bel'gova I N
Farmakol Toksikol. 1981 Nov-Dec;44(6):684-7.
Experiments in vitro were made to record isotonic contractions of isolated strips of the rectum and colon of rats distributed into 4 age groups. It was shown that in one-week-old rats, the rectal and colonic strips reacted to carbacholine (1 x 10(-10--1 x 10(-5) M) to a far less extent than those in adult rats. In the course of postnatal development the reaction of the colonic strips to carbacholine reached the adult rat level more rapidly. Pretreatment of the colonic strips from one- and two-week-old rats with pentamine solutions (2 x 10(-5)--1 x 10(-4) M) led to the increased carbacholine response rather than to its lowering which was the case in the adult animals. Pretreatment of the strips in question with atropine solutions (1 x 10(-14)--1 x 10(-6) M) decreased the response to the cholinomimetic to a more significant extent than in the adult animals. High concentrations of the cholinomimetic did induce a considerable percentage of contractions.
进行了体外实验，以记录分为4个年龄组的大鼠离体直肠和结肠条带的等张收缩。结果表明，一周龄大鼠的直肠和结肠条带对卡巴胆碱（1×10⁻¹⁰ - 1×10⁻⁵M）的反应程度远低于成年大鼠。在出生后的发育过程中，结肠条带对卡巴胆碱的反应更快达到成年大鼠水平。用五胺溶液（2×10⁻⁵ - 1×10⁻⁴M）预处理一周龄和两周龄大鼠的结肠条带，导致卡巴胆碱反应增加，而不是像成年动物那样降低。用阿托品溶液（1×10⁻¹⁴ - 1×10⁻⁶M）预处理上述条带，对拟胆碱药的反应比成年动物下降得更明显。高浓度的拟胆碱药确实诱导了相当比例的收缩。
