口腔扁平苔藓患者的唾液和血清瘦素水平。一项病例对照研究。
Salivary and serum leptin levels in oral lichen planus patients. A case-control study.
作者信息
Fawzy El Nomrosy Bahaa Mahmoud, Rashawn Weam Ahmed Maher, Shaker Olfat Gamil
机构信息
B.D.S. Misr University for Science and Technology (2015), Giza, Egypt.
Diagnosis & Periodontology-Faculty of Dentistry, Cairo University, Cairo, Egypt.
出版信息
BDJ Open. 2025 Aug 5;11(1):72. doi: 10.1038/s41405-025-00358-0.
BACKGROUND
Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) is a chronic inflammatory disease that affects the oral mucosa. Different clinical types of oral lichen planus can be diagnosed based on clinical presentation and histopathological features.
AIM
The present study aimed to assess the potential of salivary and serum leptin in the diagnosis of OLP.
MATERIALS & METHODS: The study was conducted on 78 cases (i.e., 39 cases per group) with OLP. The subjects were systematically free. Salivary and serum leptin concentrations from patients exhibiting a classic OLP and from healthy controls were assessed.
RESULTS
Salivary and serum leptin levels are higher in the OLP group. The participants in the study are older than those in the control group; therefore, the age difference between the two groups does not affect the study's results.
CONCLUSION
Salivary and serum leptin levels in OLP patients were higher than in healthy control subjects, suggesting a possible role in the process of OLP pathogenesis.
背景
扁平苔藓（LP）是一种慢性炎症性疾病。口腔扁平苔藓（OLP）是一种影响口腔黏膜的慢性炎症性疾病。不同临床类型的口腔扁平苔藓可根据临床表现和组织病理学特征进行诊断。
目的
本研究旨在评估唾液和血清瘦素在口腔扁平苔藓诊断中的潜力。
材料与方法
对78例口腔扁平苔藓患者（即每组39例）进行研究。受试者系统健康。评估表现为典型口腔扁平苔藓的患者和健康对照者的唾液和血清瘦素浓度。
结果
口腔扁平苔藓组的唾液和血清瘦素水平较高。研究中的参与者比对照组的参与者年龄大；因此，两组之间的年龄差异不影响研究结果。
结论
口腔扁平苔藓患者的唾液和血清瘦素水平高于健康对照者，提示其在口腔扁平苔藓发病过程中可能发挥作用。
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