Cheng Yi-Shing Lisa, Gould Alan, Kurago Zoya, Fantasia John, Muller Susan
Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA.
Louisville Oral Pathology Laboratory, Louisville, KY, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Sep;122(3):332-54. doi: 10.1016/j.oooo.2016.05.004. Epub 2016 Jul 9.
Despite being one of the most common oral mucosal diseases and recognized as early as 1866, oral lichen planus (OLP) is still a disease without a clear etiology or pathogenesis, and with uncertain premalignant potential. More research is urgently needed; however, the research material must be based on an accurate diagnosis. Accurate identification of OLP is often challenging, mandating inclusion of clinico-pathological correlation in the diagnostic process. This article summarizes current knowledge regarding OLP, discusses the challenges of making an accurate diagnosis, and proposes a new set of diagnostic criteria upon which to base future research studies. A checklist is also recommended for clinicians to provide specific information to pathologists when submitting biopsy material. The diagnostic process of OLP requires continued clinical follow-up after initial biopsy, because OLP mimics can manifest, necessitating an additional biopsy for direct immunofluorescence study and/or histopathological evaluation in order to reach a final diagnosis.
尽管口腔扁平苔藓（OLP）是最常见的口腔黏膜疾病之一，早在1866年就已被认识到，但它仍然是一种病因和发病机制尚不明确、恶变潜能不确定的疾病。迫切需要更多的研究；然而，研究材料必须基于准确的诊断。准确识别OLP往往具有挑战性，这就要求在诊断过程中纳入临床病理相关性。本文总结了关于OLP的现有知识，讨论了准确诊断的挑战，并提出了一套新的诊断标准，以供未来的研究参考。还建议临床医生在提交活检材料时使用检查表，以便向病理学家提供具体信息。OLP的诊断过程在初次活检后需要持续的临床随访，因为可能会出现OLP的模仿病变，需要再次活检进行直接免疫荧光研究和/或组织病理学评估，以得出最终诊断。
