Meng Xiangchun, Xiao Xiao, Jeon Sera, Cho Daniel Sanghyun, Zhang Kejia, Kwon Yong Hyun, Mo Hyeon, Park Yoojin, Park Byung-Joon, Kim Dabin, Pang Fengyi, Kim SeongMin, Choi Byung-Ok, Dai Keren, Kim Sang-Woo
Center for Human-oriented Triboelectric Energy Harvesting, Yonsei University, Seoul, Republic of Korea.
Department of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea.
Nat Commun. 2025 Aug 5;16(1):7220. doi: 10.1038/s41467-025-62312-w.
Conventional wound closure techniques, such as suturing and stapling, often cause infection, delayed healing, and tissue damage, particularly in fragile or compromised tissues. A sutureless, battery-free adhesive strip (SBF strip) is developed to integrate shape-memory-assisted mechanical approximation with impedance-matched electrical stimulation for enhanced tissue repair. The device incorporates a shape memory polymer (SMP) responsive at near-body temperature and a robust wet-adhesive interface (> 200 J m), enabling rapid attachment and uniform closure under mild heating (40 °C). A built-in ultrasound-driven triboelectric system achieves optimal skin-impedance matching (~50 kΩ), generating electric fields up to 0.59 kV m under 0.5 W cm to promote cellular migration and proliferation. Finite element simulations reveal that SMP-induced contraction redistributes local mechanical strain, reducing scarring. In vivo rat studies demonstrate a 61.7% reduction in scar area compared to sutures, along with improved epithelial regeneration, collagen deposition, and angiogenesis. This mechanically and electrically synergistic platform offers a scalable, battery-free wound therapy strategy, reducing dependence on external power and disposable components while enabling precision-guided healing.
传统的伤口闭合技术,如缝合和钉合,常常会导致感染、愈合延迟和组织损伤,尤其是在脆弱或受损的组织中。一种无需缝合、无需电池的粘合带(SBF带)被开发出来,它将形状记忆辅助机械贴合与阻抗匹配电刺激相结合,以促进组织修复。该装置包含一种在接近体温时响应的形状记忆聚合物(SMP)和一个坚固的湿粘合界面(>200 J m),能够在温和加热(40°C)下快速附着并均匀闭合。一个内置的超声驱动摩擦电系统实现了最佳的皮肤阻抗匹配(~50 kΩ),在0.5 W cm的功率下产生高达0.59 kV m的电场,以促进细胞迁移和增殖。有限元模拟表明,SMP引起的收缩会重新分布局部机械应变,减少疤痕形成。体内大鼠研究表明,与缝合相比,疤痕面积减少了61.7%,同时上皮再生、胶原蛋白沉积和血管生成也得到了改善。这个机械和电协同的平台提供了一种可扩展的、无需电池的伤口治疗策略,减少了对外部电源和一次性组件的依赖,同时实现了精确引导的愈合。
Cochrane Database Syst Rev. 2017-11-3
Cochrane Database Syst Rev. 2013-9-5
Cochrane Database Syst Rev. 2015-9-3
Nat Commun. 2024-6-3
Chem Rev. 2023-12-27
Nat Commun. 2023-11-11
J Obstet Gynaecol Can. 2024-1