Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Chem Rev. 2023 Dec 27;123(24):14084-14118. doi: 10.1021/acs.chemrev.3c00380. Epub 2023 Nov 16.
Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.
生物黏合剂在医疗保健领域已经成为具有变革性和多功能性的工具，能够轻松且最小程度地损伤组织。这些材料为组织修复和生物医学设备集成提供了众多机会，创造了一个广泛的应用领域，引起了临床和科学界的共同关注。然而，要充分发挥其潜力，需要涉及最佳黏附性、合适的生物相互作用和高效信号传递的多方面设计策略。在这篇综述中，我们深入探讨了生物黏合剂设计的这些关键方面，强调了其在生物医学应用方面的最新进展，并确定了生物黏合剂作为多功能技术平台的未来潜在机遇。
