Beamsley Keat, Hosono Nobuhiko, Uemura Takashi
Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan.
Nat Commun. 2025 Aug 5;16(1):6984. doi: 10.1038/s41467-025-62322-8.
Accomplishing multiple synthetic tasks in parallel, including substrate capture, separation, and reaction, along with controlled arrangement of product, all in one system has remained a long-standing challenge in synthetic chemistry. Here, we report a sorting polymerization strategy that harnesses the multifunctional nature of a bichannel metal-organic framework (MOF). The MOF, [Cu(5-methylisophthalate)], featuring two distinct one-dimensional channels arranged in a single Kagome lattice, allows selective adsorption of monomers to different sites based on their polarity and size. This enables the sorting of different vinyl monomers and their in-situ parallel homo-polymerization within the respective channels. The process produces alternating single-chain arrays of homopolymers in a single step, a configuration unattainable by conventional approaches. Additionally, the introduction of inter-chain cross-linking allows for the isolation of the binary polymer array by removing the MOF template. This work highlights the potential of MOFs as versatile reaction platforms for the synthesis of complex, well-ordered molecular architectures from chaotic mixtures of raw materials.
在一个系统中并行完成多个合成任务，包括底物捕获、分离和反应，以及产物的可控排列，长期以来一直是合成化学领域的一项挑战。在此，我们报道了一种分选聚合策略，该策略利用了双通道金属有机框架（MOF）的多功能性质。这种MOF，即[Cu(5-甲基间苯二甲酸酯)]，具有排列在单个 Kagome 晶格中的两个不同的一维通道，能够根据单体的极性和大小将其选择性吸附到不同位点。这使得不同的乙烯基单体得以分选，并在各自的通道内原位并行进行均聚反应。该过程一步就能生成交替排列的均聚物单链阵列，这是传统方法无法实现的构型。此外，引入链间交联可通过去除MOF模板来分离二元聚合物阵列。这项工作突出了MOF作为通用反应平台的潜力，可用于从原料的混沌混合物中合成复杂、有序的分子结构。
