de Maubeuge J, Reding P, Tielemans C, Dratwa M, Van Laethem Y, Achten G
Dermatologica. 1985;171(5):349-54.
2 cases of cutaneous vasculitis associated with chronic hepatitis and mixed cryoglobulinaemia are reported. Further studies revealed in the first case hypocomplementaemia and glomerulonephritis. The cutaneous lesions of this patient responded dramatically to plasma exchange whereas prednisolone 20 mg/day and azathioprine 50 mg/day for 10 months showed no effect. The second case (chronic active hepatitis with acute colitis) responded well to prednisolone and azathioprine. The cutaneous lesions (vascularitis) may be the only clinical symptom of a chronic hepatitis and the study of those cases sometimes allows an early diagnosis of renal failure to be made.
报告了2例与慢性肝炎和混合性冷球蛋白血症相关的皮肤血管炎病例。进一步研究发现,第一例患者存在低补体血症和肾小球肾炎。该患者的皮肤病变对血浆置换有显著反应,而每日20毫克泼尼松龙和每日50毫克硫唑嘌呤治疗10个月则无效果。第二例患者(慢性活动性肝炎伴急性结肠炎)对泼尼松龙和硫唑嘌呤反应良好。皮肤病变(血管炎)可能是慢性肝炎的唯一临床症状,对这些病例的研究有时可实现肾衰竭的早期诊断。