丙酮对大鼠乙酰乙酸脱羧酶的抑制作用。
Rat acetoacetic acid decarboxylase inhibition by acetone.
作者信息
López-Soriano F J, Alemany M, Argilés J M
出版信息
Int J Biochem. 1985;17(11):1271-3. doi: 10.1016/0020-711x(85)90019-9.
PMID:4076528
Abstract
Although in mammals, acetone formation from acetoacetic acid is normally regarded as a non-enzymatic (spontaneous) process, the existence of an acetoacetic acid decarboxylase activity was postulated recently. The results imply that this enzymatic activity can be relatively important at the physiological concentrations of ketone bodies found in the rat and that acetone acts as a competitive inhibitor of this enzyme.
摘要
虽然在哺乳动物中，乙酰乙酸形成丙酮通常被认为是一个非酶促（自发）过程，但最近有人推测存在乙酰乙酸脱羧酶活性。结果表明，在大鼠体内发现的酮体生理浓度下，这种酶活性可能相对重要，并且丙酮可作为该酶的竞争性抑制剂。
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