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应用管腔对接金属支架行内镜下胆囊十二指肠吻合术治疗神经母细胞瘤患儿胆管狭窄:一例报告

Endoscopic Cholecystoduodenostomy With Lumen-Apposing Metal Stent for Bile Duct Stricture in a Child with Neuroblastoma: A Case Report.

作者信息

Cipriani Maria Stella, Piro Liliana, Palo Federico, Chiaro Andrea, Sorrentino Stefania, Gandullia Paolo, Parodi Andrea, Avanzini Stefano

机构信息

Pediatric Surgery Department, IRCCS, Istituto Giannina Gaslini, Genoa, Italy.

Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, University of Genoa, Genoa, Italy.

出版信息

European J Pediatr Surg Rep. 2025 Aug 5;13(1):e47-e50. doi: 10.1055/a-2662-2339. eCollection 2025 Jan.

Abstract

We report the use of endoscopic cholecystoduodenostomy in a 6-year-old child to manage postanastomotic stricture of the common bile duct (CBD) secondary to an intraoperative injury sustained during the resection of an abdominal neuroblastoma (NB). The patient was diagnosed with stage M NB, characterized by dissemination to the bone marrow and vertebrae, and MYCN amplification. Following multiple cycles of chemotherapy and subsequent hematopoietic stem cell transplantation, the patient was scheduled for surgical resection. Preoperative imaging identified several image-defined risk factors, including infiltration of the porta hepatis and of the duodenopancreatic complex. During the dissection of the tumor, an incidental injury to the CBD occurred, which was subsequently repaired via end-to-end anastomosis. Seven months postoperatively, the patient presented with obstructive jaundice due to an anastomotic stricture, which was successfully managed through the placement of an endoscopic ultrasound-guided lumen-apposing metal stent (LAMS) between the dilated gallbladder and the duodenum. In our experience, endoscopic cholecystoduodenostomy constitutes a novel approach for addressing postoperative iatrogenic CBD strictures in pediatric patients. Further research is warranted to elucidate its benefits and risks as well as to evaluate its long-term efficacy and potential for broader application.

摘要

我们报告了在一名6岁儿童中使用内镜下胆囊十二指肠吻合术来处理因腹部神经母细胞瘤(NB)切除术中遭受的术中损伤继发的胆总管(CBD)吻合口狭窄。该患者被诊断为M期NB,其特征为骨髓和椎骨转移以及MYCN扩增。经过多个周期的化疗和随后的造血干细胞移植后,患者计划接受手术切除。术前影像学检查发现了几个影像界定的风险因素,包括肝门和十二指肠胰头复合体的浸润。在肿瘤切除过程中,胆总管发生了意外损伤,随后通过端端吻合进行了修复。术后7个月,患者因吻合口狭窄出现梗阻性黄疸,通过在内镜超声引导下在扩张的胆囊和十二指肠之间放置管腔对合金属支架(LAMS)成功处理。根据我们的经验,内镜下胆囊十二指肠吻合术是解决小儿患者术后医源性CBD狭窄的一种新方法。有必要进行进一步研究以阐明其益处和风险,并评估其长期疗效和更广泛应用的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/083f/12324853/56106458bd7d/10-1055-a-2662-2339_26627469.jpg

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