He Li, Han Donglei, Zong Fenfen, Zhang Yan, Han Zhongyang, Xu Zenghui
Henan Cell Therapy Group Co., Ltd, Zhengzhou, China.
Shanghai Cell Therapy Group Co., Ltd, Shanghai, China.
Front Aging. 2025 Jul 22;6:1638168. doi: 10.3389/fragi.2025.1638168. eCollection 2025.
The extension of human lifespan has intensified the demand for developing more effective strategies to enhance quality of life. Age-related physiological decline and associated diseases now constitute significant societal challenges. As scientific understanding of aging mechanisms deepens, targeted intervention in the aging process is becoming increasingly feasible. Emerging evidence suggests that lifespan extension with preserved healthspan can be achieved through metabolic modulation and innovative molecular biology approaches. Notably, cell-based therapies demonstrate substantial anti-aging potential via multiple mechanisms including metabolic reprogramming, cellular repair systems, tissue regeneration, senescent cell clearance, and immunomodulation. This has catalyzed the emergence of cellular rejuvenation as a distinct discipline within anti-aging research. This review systematically examines current understanding of aging mechanisms, recent advancements in stem cell/immune cell technologies, and their clinical translation in age-related interventions. We further identify key challenges and future directions in the field, aiming to provide novel insights for extending human healthspan and improving geriatric care.
人类寿命的延长加剧了对开发更有效策略以提高生活质量的需求。与年龄相关的生理衰退和相关疾病现已构成重大的社会挑战。随着对衰老机制的科学认识不断深入，对衰老过程进行靶向干预变得越来越可行。新出现的证据表明，通过代谢调节和创新的分子生物学方法，可以在保持健康寿命的同时延长寿命。值得注意的是，基于细胞的疗法通过多种机制展现出巨大的抗衰老潜力，这些机制包括代谢重编程、细胞修复系统、组织再生、衰老细胞清除和免疫调节。这催化了细胞年轻化作为抗衰老研究中一个独特学科的出现。本综述系统地审视了当前对衰老机制的理解、干细胞/免疫细胞技术的最新进展及其在与年龄相关干预措施中的临床转化。我们进一步确定了该领域的关键挑战和未来方向，旨在为延长人类健康寿命和改善老年护理提供新的见解。
