Mojarrad Arezoo, Sadri Damirchi Esmaeil, Sheykholeslami Ali, Rezaeisharif Ali, Abbasi Vahid, Noroozi Homayoon Mohammadreza
Department of Counseling, University of Mohaghegh Ardabili, Ardabil, Iran.
Department of Neurology, Ardabil University of Medical Sciences, Ardabil, Iran.
J Aging Res. 2025 Jul 29;2025:6616509. doi: 10.1155/jare/6616509. eCollection 2025.
Today, Alzheimer's disease is one of the most common diseases, especially in old age, and it is important to help recognize and treat this disease. The purpose of this study was to compare the effectiveness of transcranial direct current stimulation (tDCS) and short-term cognitive rehabilitation protocols on the improvement of depression and anxiety symptoms in patients with mild Alzheimer's disease. The research method was an extended experiment with two experimental groups and one control group. The statistical population included all patients over 65 years of age with mild Alzheimer's who had been referred to a neurologist in 2020, and among these people, 60 people were selected through available sampling and then randomly assigned to two experimental groups and one control group. Then, the independent variables of the tDCS method for 10 sessions of 20 min once a week were applied to an experimental group and a short-term cognitive rehabilitation program of 9 sessions (90 min each session) was applied once a week to the second experimental group, and no intervention was performed on the third group. After the end of the intervention, the post-test was conducted with an interval of 1 week on the experimental and control groups. After 1 month, the studied groups were followed up again. A neuropsychological questionnaire (NPI) was used to collect information. The results showed that both studied methods caused a significant reduction in depression in both the post-test and follow-up periods, but only the tDCS method was able to maintain its reduction in the follow-up period. Also, both methods have caused a significant improvement in the anxiety variable both during the post-test and during the follow-up period. Therefore, it can be concluded that both methods can be used to improve the symptoms of depression and anxiety in patients with mild Alzheimer's disease.
如今，阿尔茨海默病是最常见的疾病之一，尤其是在老年人群中，因此帮助识别和治疗这种疾病很重要。本研究的目的是比较经颅直流电刺激（tDCS）和短期认知康复方案对轻度阿尔茨海默病患者抑郁和焦虑症状改善的效果。研究方法是一个扩展实验，包括两个实验组和一个对照组。统计人群包括2020年被转诊至神经科医生处的所有65岁以上的轻度阿尔茨海默病患者，在这些人中，通过便利抽样选取60人，然后随机分为两个实验组和一个对照组。然后，对一个实验组应用每周一次、每次20分钟、共10次的tDCS方法作为自变量，对第二个实验组应用每周一次、每次90分钟、共9次的短期认知康复方案，对第三组不进行干预。干预结束后，对实验组和对照组间隔1周进行后测。1个月后，对研究组再次进行随访。使用神经心理学问卷（NPI）收集信息。结果表明，两种研究方法在测试后和随访期均使抑郁显著降低，但只有tDCS方法在随访期能够保持其降低效果。此外，两种方法在测试后和随访期均使焦虑变量显著改善。因此，可以得出结论，两种方法均可用于改善轻度阿尔茨海默病患者的抑郁和焦虑症状。
