Daga Vandana, Uppoor Ashita, Nayak Sangeeta Umesh, Sahu Priyanka Paramita, Kadakampally David
Department of Periodontology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Int J Dent. 2025 Jul 29;2025:5585609. doi: 10.1155/ijod/5585609. eCollection 2025.
The split-mouth randomized clinical trial evaluated and compared the clinical efficacy and patient-centered outcomes of platelet-rich fibrin (PRF) combined with modified coronally advanced flap (MCAF) and minimally invasive coronally advanced flap (MICAF) techniques for the treatment of multiple adjacent gingival recession (GR) Cairo's RT1 and/or RT2. Eighteen participants with multiple GR defects were treated using MCAF + PRF and MICAF + PRF approaches in a split-mouth design. A qualified periodontist examined the periodontal clinical parameters (recession height [RH] recession width [RW], clinical attachment level [CAL] gain, probing depth [PD], keratinized tissue width [KTW], and gingival thickness [GT]) and aesthetics at baseline and 6 months later. After 7 days, 3 months, and 6 months, patient-centered outcomes relating to pain/discomfort and aesthetics were evaluated using a visual analog scale (VAS) and a questionnaire. A statistical study was performed on the variations between the original recording and the subsequent months. Both the surgical methods showed statistically significant improvements in all clinical parameters, such as RH, RW, CAL, PD, and KTW ( < 0.001). MICAF + PRF was found to have a similar clinical efficacy to MCAF + PRF for tissue gain; yet between-group differences in GT after 6 months were not statistically significant. Patient-related outcome measures (PROMs) were significantly better in MICAF + PRF with lower VAS pain scores ( < 0.001) and higher ratings of esthetic satisfaction ( < 0.001) at 6 months' follow-up. Name of the Registry: Clinical Trials Registry - India (CTRI); Registration Number: CTRI/2019/01/016994.
这项双侧对照随机临床试验评估并比较了富血小板纤维蛋白（PRF）联合改良冠向推进瓣（MCAF）技术与微创冠向推进瓣（MICAF）技术治疗多个相邻牙龈退缩（GR）开罗分级RT1和/或RT2的临床疗效及以患者为中心的治疗效果。18名患有多个GR缺损的参与者采用双侧对照设计，分别接受MCAF + PRF和MICAF + PRF治疗。一名合格的牙周病医生在基线和6个月后检查牙周临床参数（退缩高度[RH]、退缩宽度[RW]、临床附着水平[CAL]增加量、探诊深度[PD]、角化组织宽度[KTW]和牙龈厚度[GT]）以及美观情况。在术后7天、3个月和6个月，使用视觉模拟量表（VAS）和问卷对与疼痛/不适及美观相关的以患者为中心的治疗效果进行评估。对原始记录与后续几个月之间的差异进行了统计学研究。两种手术方法在所有临床参数，如RH、RW、CAL、PD和KTW方面均显示出具有统计学意义的改善（<0.001）。发现MICAF + PRF在组织增量方面与MCAF + PRF具有相似的临床疗效；然而，6个月后两组之间GT的差异无统计学意义。在6个月的随访中，MICAF + PRF组的患者相关结局指标（PROMs）明显更好，VAS疼痛评分更低（<0.001），美学满意度评分更高（<0.001）。注册机构名称：印度临床试验注册中心（CTRI）；注册号：CTRI/2019/01/016994。
