He Wen-Fei, Zeng Li-Huan, Xie Nan-Shan, Liu Hao-Xing, Cui Wen-Min, Wang Ying, Zhang Zhi-Jian, Ye Guan-Lun, Qin Zhi-Ying, Guo Zhi-Qiang, Ma Jun, Luo Jian-Fang
Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai Hospital, the Second People's Hospital of Nanhai District, Foshan, China.
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Front Med Technol. 2025 Jul 22;7:1611046. doi: 10.3389/fmedt.2025.1611046. eCollection 2025.
Identification of coronary ischemia in suspected coronary artery disease (CAD) remains challenging. Magnetocardiography (MCG) demonstrated comparably high diagnostic efficiency for detecting coronary ischemia in previous studies. However, limited evidence exists comparing MCG vs. computed tomography angiography-derived fractional flow reserve (CTFFR) in suspected CAD patients.
A total of 291 patients with CTA-confirmed diameter stenosis ranging from 30% to 90% were included and divided into two groups based on the CTFFR values, the stable coronary artery disease (SCAD) group (≤0.8) and the non-SCAD group (>0.8). Magnetic field map (MFM) parameters were employed to construct a diagnostic model. The performance of the models was evaluated using receiver operating characteristic (ROC) curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
Patients with SCAD showed a mean MCG score of 5.6 ± 2.9, while the non-SCAD group demonstrated a mean score of 2.0 ± 1.9 ( < 0.001). The area under the curve (AUC) for ROC analysis was 0.824 (95% CI: 0.772-0.877). Point 5 was selected as the operational cutoff value providing a favorable balance of sensitivity and specificity. Ultimately, MCG score yielded a sensitivity of 69.6%, specificity of 87.9%, PPV of 72.7%, NPV of 86.2%, and accuracy of 82.1%.
Compared to CTFFR, MCG demonstrated superior specificity and moderate sensitivity for detecting CAD in patients with diameter stenosis CTA ranging from 30% to 90%. It may provide an alternative to functional evaluation prior to invasive or radiation exposure methods.
在疑似冠状动脉疾病（CAD）中识别冠状动脉缺血仍然具有挑战性。在先前的研究中，心磁图（MCG）显示出在检测冠状动脉缺血方面具有相当高的诊断效率。然而，在疑似CAD患者中，比较MCG与计算机断层扫描血管造影衍生的血流储备分数（CTFFR）的证据有限。
总共纳入291例经CT血管造影（CTA）证实直径狭窄范围为30%至90%的患者，并根据CTFFR值分为两组，稳定冠状动脉疾病（SCAD）组（≤0.8）和非SCAD组（>0.8）。采用磁场图（MFM）参数构建诊断模型。使用受试者操作特征（ROC）曲线、准确性、敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）评估模型的性能。
SCAD患者的平均MCG评分为5.6±2.9，而非SCAD组的平均评分为2.0±1.9（<0.001）。ROC分析的曲线下面积（AUC）为0.824（95%CI：0.772-0.877）。选择5分作为操作截断值，可在敏感性和特异性之间取得良好平衡。最终，MCG评分的敏感性为69.6%，特异性为87.9%，PPV为72.7%，NPV为86.2%，准确性为82.1%。
与CTFFR相比，MCG在检测CTA直径狭窄范围为30%至90%的患者的CAD时表现出更高的特异性和中等敏感性。它可能为侵入性或辐射暴露方法之前的功能评估提供一种替代方法。
