• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

β受体阻滞剂中毒

Beta-Blocker Toxicity.

作者信息

Vempati Amrita, Greene P J

机构信息

Creighton University School of Medicine Phoenix Program, Valleyhealth Medical Center, Department of Emergency Medicine, Phoenix, AZ.

出版信息

J Educ Teach Emerg Med. 2025 Jul 31;10(3):S25-S54. doi: 10.21980/J8WD3X. eCollection 2025 Jul.

DOI:10.21980/J8WD3X
PMID:40766932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12320999/
Abstract

AUDIENCE

This simulation is intended to be used for emergency medicine (EM) residents (all levels) and 4th year medical students.

INTRODUCTION

Beta-blocker (BB) toxicity ranks seventh among the top 25 substances associated with fatalities, with a cardiovascular mortality rate of up to 1.4%.1,2 Patients with BB overdose may present with bradydysrhythmias, hypotension, hypoglycemia, altered mental status, and cardiogenic shock.3 Given that EM physicians are often the first to encounter such patients, EM learners need to be proficient in managing all aspects of BB toxicity.

EDUCATIONAL OBJECTIVES

By the end of the session, learners will be able to: 1) manage a patient with hypotension, and bradycardia while maintaining a broad differential, 2) evaluate the causes of hypotension by utilizing ultrasound, 3) review when to initiate vasopressors and first-line agents for beta-blocker toxicity, 4) discuss treatment algorithm for BB toxicity including high-dose insulin and, 5) discuss the risk factors for suicide.

EDUCATIONAL METHODS

This session employed high-fidelity simulation followed by an in-depth debriefing. It was conducted during the orientation for first-year EM residents, with 16 residents participating. The group was divided into two cohorts: eight residents actively managed the simulated patient, while the other eight observed.

RESEARCH METHODS

Following the simulation and debriefing, participants were surveyed online using Google Form. The survey included the following questions: 1) the case was believable, 2) the case had right amount of complexity, 3) the case helped in improving medical knowledge and patient care, 4) I feel more confident in managing undifferentiated hypotension, 5) I feel more confident in managing BB overdose, 6) the simulation environment gave me a real-life experience and, 7) the debriefing session after simulation helped improve my knowledge. Responses were collected using a Likert scale.

RESULTS

Ten participants completed the post-session survey. All respondents either agreed or strongly agreed that the case was effective in enhancing learning, medical knowledge, and patient care skills. Every participant found the debriefing session valuable and reported increased confidence in managing undifferentiated hypotension and BB toxicity.

DISCUSSION

The simulation session effectively educated participants on the management of BB toxicity, reinforcing key concepts such as the treatment of hypoglycemia, bradycardia, and hypotension. As the case unfolded, learners were required to assess refractory hypotension and initiate vasopressor therapy and specific treatments for BB toxicity. Overall, participants found the simulation beneficial for learning the management of BB overdose.

TOPICS

Beta-blocker toxicity, refractory hypotension, bradycardia, toxicology, mental health, psychiatry.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/8bcdbe7b98a5/jetem-10-3-s25f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/a708db11da47/jetem-10-3-s25f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/7db874c054c6/jetem-10-3-s25f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/b1fa5089d717/jetem-10-3-s25f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/3a3c92d878b8/jetem-10-3-s25f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/0e9f95330da7/jetem-10-3-s25f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/8bcdbe7b98a5/jetem-10-3-s25f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/a708db11da47/jetem-10-3-s25f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/7db874c054c6/jetem-10-3-s25f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/b1fa5089d717/jetem-10-3-s25f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/3a3c92d878b8/jetem-10-3-s25f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/0e9f95330da7/jetem-10-3-s25f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edca/12320999/8bcdbe7b98a5/jetem-10-3-s25f6.jpg
摘要

受众

本模拟旨在供急诊医学(EM)住院医师(各级)和四年级医学生使用。

引言

β受体阻滞剂(BB)中毒在导致死亡的25种物质中排名第七,心血管死亡率高达1.4%。1,2 BB过量的患者可能出现缓慢性心律失常、低血压、低血糖、精神状态改变和心源性休克。3鉴于急诊医生常常是首批接触此类患者的人,急诊医学学习者需要熟练掌握BB中毒各方面的处理。

教育目标

课程结束时,学习者将能够:1)在保持广泛鉴别诊断的同时处理低血压和心动过缓患者;2)利用超声评估低血压的原因;3)回顾何时启动血管升压药和治疗BB中毒的一线药物;4)讨论BB中毒的治疗算法,包括大剂量胰岛素;5)讨论自杀的风险因素。

教育方法

本课程采用高保真模拟,随后进行深入的总结汇报。课程在一年级急诊医学住院医师入职培训期间进行,有16名住院医师参与。该组被分为两个队列:8名住院医师积极处理模拟患者,另外8名进行观察。

研究方法

模拟和总结汇报后,通过谷歌表单对参与者进行在线调查。调查包括以下问题:1)病例是否可信;2)病例的复杂程度是否合适;3)病例是否有助于提高医学知识和患者护理水平;4)我对处理未分化性低血压更有信心;5)我对处理BB过量更有信心;6)模拟环境是否给了我真实的体验;7)模拟后的总结汇报环节是否有助于提高我的知识水平。使用李克特量表收集回答。

结果

10名参与者完成了课后调查。所有受访者均同意或强烈同意该病例在增强学习、医学知识和患者护理技能方面是有效的。每位参与者都认为总结汇报环节很有价值,并表示在处理未分化性低血压和BB中毒方面信心增强。

讨论

模拟课程有效地让参与者了解了BB中毒的处理方法,强化了诸如低血糖、心动过缓和低血压治疗等关键概念。随着病例的展开,学习者需要评估难治性低血压并启动血管升压药治疗以及针对BB中毒的特定治疗。总体而言,参与者发现模拟对学习BB过量的处理很有帮助。

主题

β受体阻滞剂中毒、难治性低血压、心动过缓、毒理学、心理健康、精神病学。

相似文献

1
Beta-Blocker Toxicity.β受体阻滞剂中毒
J Educ Teach Emerg Med. 2025 Jul 31;10(3):S25-S54. doi: 10.21980/J8WD3X. eCollection 2025 Jul.
2
A Recipe for Disaster - Sodium Bicarbonate Overdose.灾难处方——碳酸氢钠过量
J Educ Teach Emerg Med. 2025 Jul 31;10(3):O1-O33. doi: 10.21980/J8MW85. eCollection 2025 Jul.
3
A Comprehensive and Modality Diverse Cervical Spine and Back Musculoskeletal Physical Exam Curriculum for Medical Students.面向医学生的全面且多模态的颈椎和背部肌肉骨骼物理检查课程
J Educ Teach Emerg Med. 2025 Jul 31;10(3):SG1-SG8. doi: 10.21980/J8RQ0N. eCollection 2025 Jul.
4
Sexual Harassment and Prevention Training性骚扰与预防培训
5
Posterior Reversible Encephalopathy Syndrome and Eclampsia.后部可逆性脑病综合征与子痫
J Educ Teach Emerg Med. 2025 Jul 31;10(3):O34-O57. doi: 10.21980/J8H64T. eCollection 2025 Jul.
6
Critical Care Transport: Blunt Polytrauma in Pregnancy.重症监护转运:妊娠期钝性多发伤
J Educ Teach Emerg Med. 2025 Jul 31;10(3):S1-S24. doi: 10.21980/J81366. eCollection 2025 Jul.
7
Health professionals' experience of teamwork education in acute hospital settings: a systematic review of qualitative literature.医疗专业人员在急症医院环境中团队合作教育的经验:对定性文献的系统综述
JBI Database System Rev Implement Rep. 2016 Apr;14(4):96-137. doi: 10.11124/JBISRIR-2016-1843.
8
A New Measure of Quantified Social Health Is Associated With Levels of Discomfort, Capability, and Mental and General Health Among Patients Seeking Musculoskeletal Specialty Care.一种新的量化社会健康指标与寻求肌肉骨骼专科护理的患者的不适程度、能力以及心理和总体健康水平相关。
Clin Orthop Relat Res. 2025 Apr 1;483(4):647-663. doi: 10.1097/CORR.0000000000003394. Epub 2025 Feb 5.
9
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
10
Impact of residual disease as a prognostic factor for survival in women with advanced epithelial ovarian cancer after primary surgery.原发性手术后晚期上皮性卵巢癌患者残留病灶对生存预后的影响。
Cochrane Database Syst Rev. 2022 Sep 26;9(9):CD015048. doi: 10.1002/14651858.CD015048.pub2.

本文引用的文献

1
A Clinical-Epidemiological Study on Beta-Blocker Poisonings Based on the Type of Drug Overdose.基于药物过量类型的β受体阻滞剂中毒临床流行病学研究
J Toxicol. 2023 Feb 24;2023:1064955. doi: 10.1155/2023/1064955. eCollection 2023.
2
Treatment for beta-blocker poisoning: a systematic review.β受体阻滞剂中毒的治疗:一项系统评价。
Clin Toxicol (Phila). 2020 Oct;58(10):943-983. doi: 10.1080/15563650.2020.1752918. Epub 2020 Apr 20.