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压力对大脑及恐惧的影响。

The consequences of stress on the brain and fear.

作者信息

Ferrara Nicole C, Trask Sydney

机构信息

Center for Neurobiology of Stress Resilience and Psychiatric Disorders, and the Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States.

Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States.

出版信息

Elife. 2025 Aug 6;14:e108480. doi: 10.7554/eLife.108480.

DOI:10.7554/eLife.108480
PMID:40767294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12327941/
Abstract

A region of the brain called the paraventricular thalamus mediates the impact of stress on unlearned fear responses, but is not involved in learned fear behavior.

摘要

大脑中一个名为室旁丘脑的区域介导了压力对先天恐惧反应的影响，但不参与后天习得的恐惧行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96b/12327941/8b0420068a8f/elife-108480-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96b/12327941/8b0420068a8f/elife-108480-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96b/12327941/8b0420068a8f/elife-108480-fig1.jpg

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本文引用的文献

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A mouse model of stress-enhanced fear learning demonstrates extinction-sensitive and extinction-resistant effects of footshock stress.应激增强恐惧学习的小鼠模型显示出足底电击应激的消退敏感和消退抵抗效应。
Behav Brain Res. 2020 Feb 3;379:112391. doi: 10.1016/j.bbr.2019.112391. Epub 2019 Nov 27.
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Timing and the transition between modes in the defensive behavior system.防御行为系统中的时间安排及模式转换
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Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder.
在创伤后应激障碍动物模型中，慢性应激会破坏恐惧消退，并增强杏仁核和海马体中的Fos表达。
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Implications of memory modulation for post-traumatic stress and fear disorders.记忆调节对创伤后应激和恐惧障碍的影响。
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Sex differences in fear conditioning in posttraumatic stress disorder.创伤后应激障碍中恐惧条件反射的性别差异。
J Psychiatr Res. 2013 Jan;47(1):64-71. doi: 10.1016/j.jpsychires.2012.08.027. Epub 2012 Oct 26.
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Stress-enhanced fear learning in rats is resistant to the effects of immediate massed extinction.大鼠应激增强的恐惧学习对即刻密集灭绝的影响具有抗性。
Stress. 2012 Nov;15(6):627-36. doi: 10.3109/10253890.2011.650251. Epub 2012 Jan 24.
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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.创伤后应激障碍与 PACAP 和 PAC1 受体有关。
Nature. 2011 Feb 24;470(7335):492-7. doi: 10.1038/nature09856.
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Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity.创伤后应激障碍的创伤平民的恐惧消除：与症状严重程度的关系。
Biol Psychiatry. 2011 Mar 15;69(6):556-63. doi: 10.1016/j.biopsych.2010.09.013. Epub 2010 Oct 29.
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Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder.杏仁核转录组和创伤后应激障碍大鼠模型中应激增强恐惧学习的细胞机制。
Neuropsychopharmacology. 2010 May;35(6):1402-11. doi: 10.1038/npp.2010.10. Epub 2010 Feb 10.