Algarra Manuel, Vinacua Sara, Gil-Korilis Adrián, Gil Antonio
INAMAT(2)-Institute for Advanced Materials and Mathematics, Science Department, Public University of Navarra, Campus of Arrosadía, 31006 Pamplona, Spain.
INAMAT(2)-Institute for Advanced Materials and Mathematics, Science Department, Public University of Navarra, Campus of Arrosadía, 31006 Pamplona, Spain.
J Control Release. 2025 Oct 10;386:114100. doi: 10.1016/j.jconrel.2025.114100. Epub 2025 Aug 5.
Cancer is one of the most complex health problems worldwide, demanding innovative approaches to achieve effective diagnosis, treatment and prevention. The field of nanomedicine, including nanomaterials and particularly carbon-based nanoparticles, has emerged as a promising candidate to transform cancer therapy. This review presents a landscape of carbon nanomaterial- and nanoparticle-based cancer interventions. First, a brief overview of the types of nanomaterials available is provided, including metal-based nanomaterials, mesoporous silicas, polymers and composites (most notably MXenes and metal-organic frameworks), proteins, and carbon-based nanomaterials, including carbon quantum dots. The latter have attracted significant attention due to their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, making them ideal candidates for cancer diagnostic and therapeutic strategies. The second part of this review focuses on briefly presenting the various therapies developed with carbon-based nanomaterials including chemo, radio, immuno, targeted, hyperthermia, photodynamic, and photothermal therapies.
癌症是全球最复杂的健康问题之一，需要创新方法来实现有效的诊断、治疗和预防。纳米医学领域，包括纳米材料，尤其是碳基纳米颗粒，已成为变革癌症治疗的有前景的候选者。本文综述了基于碳纳米材料和纳米颗粒的癌症干预措施。首先，简要概述了可用的纳米材料类型，包括金属基纳米材料、介孔二氧化硅、聚合物和复合材料（最显著的是MXenes和金属有机框架）、蛋白质，以及碳基纳米材料，包括碳量子点。后者因其出色的生物相容性、可调节的表面化学性质和独特的光学性质而备受关注，使其成为癌症诊断和治疗策略的理想候选者。本综述的第二部分重点简要介绍了用碳基纳米材料开发的各种疗法，包括化学疗法、放射疗法、免疫疗法、靶向疗法、热疗、光动力疗法和光热疗法。
