使用低真空扫描电子显微镜对肾小球基底膜中聚集微球和足细胞褶皱进行组织病理学检查。

Histopathological Examination of Clustering Microspheres and Podocyte Infolding in the Glomerular Basement Membrane Using Low-vacuum Scanning Electron Microscopy.

作者信息

Nakayama Shingo, Hirose Takuo, Hashimoto Hideaki, Endo Akari, Oba-Yabana Ikuko, Kimura Tomoyoshi, Yumura Wako, Mori Takefumi

机构信息

Division of Nephrology and Hypertension, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.

Division of Integrative Renal Replacement Therapy, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.

出版信息

Intern Med. 2025 Aug 7. doi: 10.2169/internalmedicine.5803-25.

DOI:10.2169/internalmedicine.5803-25

PMID:40769902

Abstract

Podocyte infolding (PI) in a thickened glomerular basement membrane (GBM) is a rare pathological finding in electron microscopy (EM). We histopathologically evaluated a 57-year-old Japanese male patient with clustering microspheres and PI in the GBM. EM showed clustering microspheres in irregularly thickened GBM and PI into the GBM. Endothelial cells also invaded the GBM on EM. Low-vacuum scanning EM revealed numerous openings or holes in the GBM. Careful examination by EM is needed to identify further cases of clustering microspheres and PI. It is also important to explore these cases using new approaches such as low-vacuum scanning EM.

摘要

肾小球基底膜（GBM）增厚伴足细胞内陷（PI）是电子显微镜（EM）下一种罕见的病理表现。我们对一名57岁的日本男性患者进行了组织病理学评估，该患者的GBM中存在微球聚集和PI。EM显示，在不规则增厚的GBM中有微球聚集，且有PI深入GBM。EM还显示内皮细胞侵入了GBM。低真空扫描电镜显示GBM上有许多开口或孔洞。需要通过EM仔细检查以识别更多微球聚集和PI的病例。使用低真空扫描电镜等新方法探索这些病例也很重要。