Si Xianzhe, Chen Jianan, Gao Lei, Chen Zhiyao
Department of Gastrointestinal, Hernia and Abdominal Wall Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Department of Clinical Sciences, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.
Obes Surg. 2025 Aug 6. doi: 10.1007/s11695-025-08135-6.
Ventral hernia (VH) includes subtypes like incisional and umbilical hernias, which are more complex than groin hernias due to wider defects, higher recurrence rates, and more demanding surgical techniques. The purpose of the present research is to explore the causal relationship among metabolic syndrome-related components and abdominal wall hernia, and to provide genetic evidence to support the risk of metabolic syndrome-related components and abdominal wall hernia.
Data from genome-wide association studies (GWAS) were analyzed. The study selected waist circumference (WC), hypertension, fasting blood glucose (FBG), HDL cholesterol (HDL-C), and triglycerides as exposure factors. The outcome variable was ventral hernia (VH). The causal association among exposure and outcome was assessed primarily using inverse variance-weighted (IVW), supplemented by MR-Egger, weighted median, and simple model analysis. Cochrane's Q test was used for sensitivity analysis, and the findings were presented as forest plots, scatter plots, and funnel plots.
After screening, a total of 817 instrumental variables were retained. IVW results showed a significant positive causal relationship between WC and VH (OR = 1.074, 95% CI = 1.016-1.135, p = 0.011). However, no evidence was found for a causal relationship between other metabolic syndrome related symptoms and abdominal wall hernia.
In light of genetic data, the findings imply a causal association between VH and waist circumference, a sign of metabolic syndrome. The final results confirm that an higher risk of VH is linked to an increased waist circumference.
腹疝（VH）包括切口疝和脐疝等亚型，由于缺损更宽、复发率更高以及手术技术要求更高，比腹股沟疝更复杂。本研究的目的是探讨代谢综合征相关成分与腹壁疝之间的因果关系，并提供遗传证据以支持代谢综合征相关成分与腹壁疝的风险。
分析来自全基因组关联研究（GWAS）的数据。该研究选择腰围（WC）、高血压、空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯作为暴露因素。结局变量为腹疝（VH）。主要使用逆方差加权（IVW）评估暴露与结局之间的因果关联，并辅以MR-Egger、加权中位数和简单模型分析。采用Cochrane's Q检验进行敏感性分析，研究结果以森林图、散点图和漏斗图呈现。
筛选后，共保留817个工具变量。IVW结果显示WC与VH之间存在显著的正因果关系（OR = 1.074，95% CI = 1.016 - 1.135，p = 0.011）。然而，未发现其他代谢综合征相关症状与腹壁疝之间存在因果关系的证据。
根据遗传数据，研究结果表明VH与代谢综合征的一个标志——腰围之间存在因果关联。最终结果证实，腹疝风险较高与腰围增加有关。
