Panjaitan Fajar H, Hasanah Dian Yaniarti, Yonas Emir, Soerarso Rarsari
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia.
Int J Angiol. 2023 Feb 8;34(3):226-232. doi: 10.1055/s-0043-1761271. eCollection 2025 Sep.
Heart failure (HF) affects an estimated 38 million people globally, with most published research estimating a prevalence of 1 to 2% of the adult population. Low blood pressure (BP) is reported in 10 to 15% of patients with HF in clinical trials, although this proportion is much more frequent in routine clinical practice. Low BP in outpatients has a better outcome compared to inpatients. Low BP is often a restricting factor in the use and uptitration of guideline-directed medical therapy (GDMT). A 57-year-old male presented himself to the HF clinic with complaints of bloating, shortness of breath, and fatigue. The patient had a history of acute coronary syndrome and cardiac arrest, but the results of coronary angiography showed nonsignificant coronary artery disease. Cardiomegaly was seen on chest X-ray. Electrocardiogram showed pathologic q wave II, III, and AvF with poor r wave progression on V1-V6. The patient was admitted due to acute decompensated HF with hypotension. After the initial decongestion patient was treated with sacubitril/valsartan, bisoprolol, and spironolactone in the outpatient clinic. Patient complaints and BP slowly improved during the outpatient phase. Hypotension remains a challenge in implementing GDMT in HF patients. By following the steps according to algorithm and current guidelines, GDMT can be optimized in these patients.
心力衰竭(HF)全球估计影响3800万人,大多数已发表的研究估计其在成年人口中的患病率为1%至2%。在临床试验中,10%至15%的HF患者报告有低血压(BP),尽管在常规临床实践中这一比例更为常见。门诊患者的低血压与住院患者相比预后较好。低血压往往是使用和滴定指南导向的药物治疗(GDMT)的限制因素。一名57岁男性因腹胀、呼吸急促和疲劳就诊于HF门诊。该患者有急性冠状动脉综合征和心脏骤停病史,但冠状动脉造影结果显示冠状动脉疾病不显著。胸部X线显示心脏扩大。心电图显示II、III和AvF导联有病理Q波,V1-V6导联R波进展不良。患者因急性失代偿性HF伴低血压入院。初始消肿后,患者在门诊接受沙库巴曲缬沙坦、比索洛尔和螺内酯治疗。在门诊阶段,患者的症状和血压缓慢改善。低血压仍然是在HF患者中实施GDMT的一个挑战。通过按照算法和当前指南的步骤操作,可以在这些患者中优化GDMT。