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利用纳米技术进行干细胞治疗：革新神经退行性疾病的治疗——最新进展

Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments - a state-of-the-art update.

作者信息

Chengebroyen Neevashini, Seelan Anmol, Yoonus Thajudeen Kamal, Alshehri Saad Ali, Biswas Aritra, Adur Israrahmed, Sundararajan Vino, Lulu Sudhakaran Sajitha, Singh Harpreet

机构信息

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia.

Department of Biological Sciences, Sunandan Divatia School of Science, Narsee Monjee Institute of Management Studies (NMIMS), Mumbai, India.

出版信息

Front Pharmacol. 2025 Jul 23;16:1630475. doi: 10.3389/fphar.2025.1630475. eCollection 2025.

DOI:10.3389/fphar.2025.1630475
PMID:40771915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12325240/
Abstract

Neurodegenerative disorders, marked by the gradual degeneration and dysfunction of neurons, pose substantial clinical challenges due to the paucity of effective therapeutic strategies and the intricate and multifactorial nature of their underlying pathophysiology. On the other hand nanotechnology, Recent advancements in nanotechnology-driven interventions have significantly augmented the therapeutic potential of stem-cell therapies for the treatment of these complex conditions. Critical limitations in current therapeutic approaches have been highlighted, while potential future directions for their therapy have been outlined. Stem cell types-embryonic, induced pluripotent, and adult neural stem cells-are categorized, with a focus on their unique biological properties and therapeutic potentials in addressing neurodegenerative conditions. The role of nanomaterials in augmenting stem cell generation, scaffold fabrication, and targeted delivery mechanisms is examined, with particular emphasis on the capacity of nanotechnology to enhance regenerative processes and neuroprotective interventions. Nanomaterial-conjugated stem cell therapies are specifically addressed, focusing on their applications in neuronal recovery and treatment monitoring. Challenges associated with stem cell therapies, including ethical considerations, immunogenicity, and the necessity for stringent clinical validation, are critically examined. The integration of nanomedicine with stem cell research is proposed as a promising strategy to overcome these challenges and facilitate the development of novel therapeutic approaches. A comprehensive framework for future research is proposed, focusing on the synergistic integration of nanotechnological advancements with stem cell therapies to improve clinical outcomes and drive innovation in the treatment of neurodegenerative disorders. By integrating existing knowledge and highlighting critical gaps, this review seeks to foster continued research and interdisciplinary collaboration, accelerating progress in this rapidly evolving field.

摘要

神经退行性疾病以神经元的逐渐退化和功能障碍为特征，由于缺乏有效的治疗策略以及其潜在病理生理学的复杂和多因素性质，带来了重大的临床挑战。另一方面，纳米技术。纳米技术驱动的干预措施的最新进展显著增强了干细胞疗法治疗这些复杂病症的治疗潜力。文中强调了当前治疗方法的关键局限性，同时概述了其治疗的潜在未来方向。对干细胞类型——胚胎干细胞、诱导多能干细胞和成体神经干细胞进行了分类，重点关注它们在解决神经退行性疾病方面独特的生物学特性和治疗潜力。研究了纳米材料在增强干细胞生成、支架制造和靶向递送机制中的作用，特别强调了纳米技术增强再生过程和神经保护干预的能力。具体讨论了纳米材料共轭干细胞疗法，重点关注其在神经元恢复和治疗监测中的应用。对与干细胞疗法相关的挑战，包括伦理考量、免疫原性以及严格临床验证的必要性进行了批判性审视。提出将纳米医学与干细胞研究相结合是克服这些挑战并促进新型治疗方法发展的一种有前景的策略。提出了一个未来研究的综合框架，重点是将纳米技术进展与干细胞疗法协同整合，以改善临床结果并推动神经退行性疾病治疗的创新。通过整合现有知识并突出关键差距，本综述旨在促进持续研究和跨学科合作，加速这一快速发展领域的进展。

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本文引用的文献

[1]
Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases.

Stem Cell Res Ther. 2024-12-18

[2]
Nanotechnology at the crossroads of stem cell medicine.

Biomater Sci. 2024-12-17

[3]
Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance.

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Stem Cell Res Ther. 2024-6-1

[5]
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer's disease.

Int J Oral Sci. 2024-5-13

[6]
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Lancet. 2024-5-18

[7]
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Stem Cells. 2024-6-14

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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.

Ann Neurol. 2024-4

[9]
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