Khaloui Ghizlane, Abchir Salma, Mabkhout Amal, Rachidi Linda, Benjelloun Ghizlane
Child and Adolescent Psychiatry Department, Abderrahim Harouchi Mother-Child Hospital, Ibn Rochd University Hospital Center, Laboratory of Clinical Neurosciences and Mental Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MAR.
Cureus. 2025 Aug 5;17(8):e89413. doi: 10.7759/cureus.89413. eCollection 2025 Aug.
Catatonia is a severe but often underrecognized neuropsychiatric condition in adolescents. We present the case of a 16-year-old girl with early-onset schizophrenia who developed acute catatonic symptoms during a relapse following risperidone reintroduction. The clinical presentation raised a diagnostic dilemma with neuroleptic malignant syndrome (NMS). A lorazepam trial led to partial improvement, but symptom resolution occurred only after adding low-dose aripiprazole. This case underscores the importance of early identification of catatonia in adolescents, careful differentiation from NMS, and the potential benefit of combined lorazepam and aripiprazole treatment in catatonic schizophrenia.
紧张症是青少年中一种严重但常未被充分认识的神经精神疾病。我们报告一例16岁早发性精神分裂症女孩的病例，该女孩在重新引入利培酮后复发期间出现了急性紧张症症状。临床表现引发了与抗精神病药物恶性综合征（NMS）的诊断困境。劳拉西泮试验使症状部分改善，但仅在加用小剂量阿立哌唑后症状才得以缓解。该病例强调了青少年中早期识别紧张症的重要性、与NMS的仔细鉴别以及劳拉西泮和阿立哌唑联合治疗紧张型精神分裂症的潜在益处。
