Arenas Sanchez Kelly A, Caicedo Vásquez Pedro G, Sandoval Calle Lina M, Huertas José F, Vinueza Jaime M
Internal Medicine, Centro Medico Nacional 20 de Noviembre, Mexico City, MEX.
Internal Medicine, Clínica Nueva Rafael Uribe Uribe, Cali, COL.
Cureus. 2025 Jul 6;17(7):e87372. doi: 10.7759/cureus.87372. eCollection 2025 Jul.
Leprosy is a chronic infectious and granulomatous disease that occurs predominantly in tropical regions, primarily affecting the skin, mucous membranes, and peripheral nervous system. It is caused by and . It is characterized by hypopigmented lesions, sensory disturbances, absence of hair in the affected area, and anhidrosis, although some of these manifestations may not be initially present. Leprosy remains a public health challenge due to its wide spectrum of clinical manifestations and leprosy-related reactions. It is a potentially curable disease, especially since the introduction of multidrug therapy (MDT) as the standard treatment, provided that diagnosis and treatment are initiated early. Lucio's phenomenon is a rare leprosy reaction characterized by extensive necrotic skin lesions and multisystem involvement, with a high rate of morbidity and mortality. Its treatment remains challenging. Currently, the recommended therapy includes the initiation of MDT-comprising dapsone, clofazimine, and rifampicin-combined with systemic corticosteroids and specialized wound care. In cases of secondary bacterial infection, the use of antibiotics is advised based on local epidemiological data. We present the case of a patient with Lucio's phenomenon who was treated with combined MDT and systemic corticosteroids, resulting in significant clinical improvement.
麻风病是一种慢性传染性肉芽肿性疾病，主要发生在热带地区，主要影响皮肤、粘膜和周围神经系统。它由[此处原文缺失病原体相关内容]引起。其特征为色素减退性皮损、感觉障碍、受累区域无毛发以及无汗，尽管这些表现最初可能并不都出现。由于其广泛的临床表现和麻风病相关反应，麻风病仍然是一项公共卫生挑战。它是一种潜在可治愈的疾病，特别是自引入多药联合疗法（MDT）作为标准治疗以来，前提是早期进行诊断和治疗。卢西奥现象是一种罕见的麻风病反应，其特征为广泛的坏死性皮肤病变和多系统受累，发病率和死亡率很高。其治疗仍然具有挑战性。目前，推荐的治疗方法包括开始使用由氨苯砜、氯法齐明和利福平组成的MDT，联合全身用皮质类固醇和专门的伤口护理。在继发细菌感染的情况下，建议根据当地流行病学数据使用抗生素。我们报告了一例卢西奥现象患者，该患者接受了MDT和全身用皮质类固醇联合治疗，临床症状得到显著改善。
