Oyeleye-Adegbite Oluwabukola C, Ozojide Kingsley O, Akinade Omotola, Oguntuase Feyisayo O, Okeji Izuchukwu E, Odedele Joy A, Adepeko Oluwagbeminiyi M, Ehi Egege Stella, Okobi Okelue E
Public Health, Texas A&M University, College Station, USA.
Public Health, Nottingham Trent University, Nottingham, GBR.
Cureus. 2025 Jul 7;17(7):e87442. doi: 10.7759/cureus.87442. eCollection 2025 Jul.
Type 2 diabetes mellitus (T2DM) and depression commonly co-occur, and antidepressants are frequently prescribed. However, their potential impact on glycemic control remains unclear.
This study aimed to evaluate the association between antidepressant use and hemoglobin A1c (HbA1c) levels among U.S. adults with comorbid T2DM and depression.
This study used data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). Adults with both T2DM and depression were included. Descriptive statistics and survey-weighted multivariable linear regression were used to assess the relationship between antidepressant use and HbA1c, adjusting for age, gender, race/ethnicity, and BMI.
Among 11,141,019 weighted individuals, 6.7% reported antidepressant use. No significant difference in HbA1c levels was found between users and non-users of antidepressants (adjusted beta (β) = 0.091, p = 0.118). Age was inversely associated with HbA1c, while BMI showed a modest positive relationship.
Antidepressant use was not significantly associated with HbA1c levels in U.S. adults with T2DM and depression. Further research is needed to explore the effects of specific antidepressant types and behavioral factors on glycemic control.
2型糖尿病（T2DM）和抑郁症常同时出现，抗抑郁药的处方也很常见。然而，它们对血糖控制的潜在影响仍不清楚。
本研究旨在评估美国患有T2DM合并抑郁症的成年人中，使用抗抑郁药与糖化血红蛋白（HbA1c）水平之间的关联。
本研究使用了2005 - 2018年美国国家健康和营养检查调查（NHANES）的数据。纳入患有T2DM和抑郁症的成年人。采用描述性统计和调查加权多变量线性回归来评估使用抗抑郁药与HbA1c之间的关系，并对年龄、性别、种族/民族和体重指数进行调整。
在11141019名加权个体中，6.7%的人报告使用了抗抑郁药。使用和未使用抗抑郁药的人之间HbA1c水平没有显著差异（调整后的β = 0.091，p = 0.118）。年龄与HbA1c呈负相关，而体重指数呈适度正相关。
在美国患有T2DM和抑郁症的成年人中，使用抗抑郁药与HbA1c水平没有显著关联。需要进一步研究来探索特定抗抑郁药类型和行为因素对血糖控制的影响。
