School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, China.
Department of Gastroenterology, Mental Health Center of Fengxian District, Shanghai, China.
Front Cell Infect Microbiol. 2023 Jan 30;13:1069954. doi: 10.3389/fcimb.2023.1069954. eCollection 2023.
Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiota, serum metabolism and emotional mood of patients with T2DM after consumption of a high-fiber diet. The glucose homeostasis of participants with T2DM was improved by the high-fiber diet, and the serum metabolome, systemic inflammation and psychiatric comorbidities were also altered. The increased abundances of , and revealed that the proportions of beneficial gut microbes were enriched by the high-fiber diet, while the abundances of , and other opportunistic pathogens were decreased. Therefore, the current study demonstrated that the intestinal microbiota alterations which were influenced by the high-fiber diet could improve the serum metabolism and emotional mood of patients with T2DM.
先前的研究表明，2 型糖尿病（T2DM）患者常存在粪便微生物群落失调的问题，通常伴有精神共病（如抑郁和焦虑）。在这里，我们进行了一项随机临床试验，以分析高纤维饮食对 T2DM 患者肠道微生物群、血清代谢和情绪的变化。高纤维饮食改善了 T2DM 患者的血糖稳态，同时也改变了血清代谢组、全身炎症和精神共病。 、 和 的丰度增加表明，高纤维饮食丰富了有益肠道微生物的比例，而 、 和其他机会性病原体的丰度则降低。因此，本研究表明，高纤维饮食影响的肠道微生物群的改变可以改善 T2DM 患者的血清代谢和情绪。
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