Turner S T, Johnson M, Boerwinkle E, Richelson E, Taswell H F, Sing C F
Hypertension. 1985 Nov-Dec;7(6 Pt 1):955-62. doi: 10.1161/01.hyp.7.6.955.
Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that Na-Li countertransport may serve as a marker for the genetic predisposition to hypertension. We studied Na-Li countertransport in 238 randomly selected blood donors representative of the population of Rochester, Minnesota. The mean value (+/- SD) for Na-Li countertransport in units of mmoles of lithium efflux per liter of red blood cells per hour was 0.29 +/- 0.12. The distribution of Na-Li countertransport values among the donors was continuous. An analysis for multimodality, however, detected significant evidence of bimodality with 72% of the population predicted to belong to the lower mode with a mean of 0.24 mmol/L red blood cells per hour and 28% of the population to belong to the upper mode with a mean of 0.42 mmol/L red blood cells per hour. There was a positive association between Na-Li countertransport and blood pressure; after adjustment for weight and age, Na-Li countertransport predicted approximately 3% of the variation in blood pressure. Persons belonging to the upper mode of the Na-Li countertransport distribution may be at increased risk of acquiring elevated blood pressure as they age.
研究发现，原发性高血压患者及其血压正常的后代红细胞中钠-锂逆向转运的最大速率增加，这增加了钠-锂逆向转运可能作为高血压遗传易感性标志物的可能性。我们对明尼苏达州罗切斯特市具有代表性的238名随机选择的献血者的钠-锂逆向转运进行了研究。钠-锂逆向转运的平均值（±标准差），以每升红细胞每小时锂外流的毫摩尔数为单位，为0.29±0.12。献血者中钠-锂逆向转运值的分布是连续的。然而，多峰性分析检测到显著的双峰证据，预计72%的人群属于较低模式，每小时每升红细胞的平均值为0.24 mmol/L，28%的人群属于较高模式，每小时每升红细胞的平均值为0.42 mmol/L。钠-锂逆向转运与血压之间存在正相关；在调整体重和年龄后，钠-锂逆向转运可预测约3%的血压变化。属于钠-锂逆向转运分布较高模式的人随着年龄增长患高血压的风险可能会增加。
